All papers authored by Christopher Schofield
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Nadia Saffoon,
John Walsby-Tickle ,
Svenja S. Hester,
Felix A. Dingler ,
Christopher L. Millington,
James S. O. McCullagh,
Ketan J. Patel,
Richard J. Hopkinson ,
Christopher J. Schofield
Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism
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Philip Hinchliffe ,
Michael Beer ,
Kirill Zinovjev ,
Charlotte K. Colenso,
Christopher J. Schofield ,
Adrian J. Mulholland ,
James Spencer
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Pauline A. Lang ,
Francisco De Dios Anton,
Mónica Cacho ,
Robert H. Bates ,
Jürgen Brem ,
Beatriz Rodríguez Miquel ,
Christopher J. Schofield
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Anthony Tumber,
Laust Moesgaard,
Eidarus Salah,
Jacob Kongsted ,
Christopher J. Schofield ,
Jasmin Mecinović
Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66
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Ritu Raj,
Anthony Tumber,
Christopher T. Lohans ,
Patrick Rabe ,
Carol V. Robinson ,
Jürgen Brem,
Christopher J. Schofield
Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors
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Jürgen Brem ,
Michael A. McDonough,
James Spencer,
Christopher J. Schofield
Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2
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Tharindi Panduwawala ,
Jon Ulf Hansen,
Joanne Hewitt,
Edgars Liepins,
Pawel Donets ,
Laura Espina,
Alistair J. M. Farley,
Kirill Shubin,
Gonzalo Gomez Campillos ,
Paula Kiuru ,
Shifali Shishodia ,
Daniel Krahn,
Robert K. Leśniak,
Juliane Schmidt
and 46 other authors
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors
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Jos J. A. G. Kamps ,
Kyle D. Sutherlin ,
James D. S. Linyard,
Pierre Aller,
Cindy C. Pham,
Hiroki Makita,
Ian Clifton ,
Michael A. McDonough,
Thomas M. Leissing,
Denis Shutin,
Pauline A. Lang ,
Agata Butryn,
Jürgen Brem ,
Sheraz Gul
and 26 other authors
X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis
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Philipp S. Simon ,
Pierre Aller ,
Philip Hinchliffe ,
Ramzi N. Massad,
Gabriel Leen,
Catherine L. Tooke ,
Isabel Bogacz,
In-Sik Kim,
Asmit Bhowmick,
Aaron S. Brewster ,
Nicholas E. Devenish,
Jürgen Brem ,
Jos J. A. G. Kamps ,
Pauline A. Lang
and 21 other authors
An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography
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Tika R. Malla,
Catherine L. Tooke ,
Jürgen Brem,
Karina Calvopiña,
Christopher T. Lohans,
Patrick Rabe,
Michael A. McDonough ,
Timothy Armistead,
Allen M. Orville ,
James Spencer ,
Christopher J. Schofield
Faropenem reacts with serine and metallo-β-lactamases to give multiple products
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Philip Hinchliffe ,
Robert A. Bonomo ,
Christopher J. Schofield ,
Adrian J. Mulholland ,
James Spencer
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Thomas M. Leissing,
Malcolm G. P. Page,
Christopher J. Schofield ,
Jürgen Brem
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John H. Beale,
Agata Butryn ,
Pierre Aller ,
Anna Dirr ,
Pauline A. Lang ,
Danny N. Axford ,
Stephen B. Carr ,
Thomas M. Leissing,
Micheal A. McDonough,
Bradley Davy,
Ali Ebrahim ,
Julien Orlans ,
Selina L. S. Storm ,
Allen M. Orville
and 2 other authors
Anaerobic fixed-target serial crystallography
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Anete Parkova,
Thomas M. Leissing,
Karina Calvopiña ,
Ricky Cain,
Alen Krajnc ,
Tharindi D. Panduwawala ,
Jules Philippe,
Colin W. G. Fishwick,
Peteris Trapencieris,
Malcolm G. P. Page ,
Christopher J. Schofield ,
Jürgen Brem
Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli
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Lynsey M. Meikle,
Nicole Strittmatter ,
Justin J. J. van der Hooft ,
John Swales ,
Ryan A. Bragg ,
Victor H. Villar ,
Michael J. Ormsby ,
Stephanie Barnes,
Sheila L. Brown,
Alex Dexter ,
Maya T. Kamat,
Jasper C. Komen,
Daniel Walker,
Simon Milling
and 11 other authors
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication
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Philip Hinchliffe ,
Alen Krajnc ,
Adrian J. Mulholland,
Jürgen Brem ,
Christopher J. Schofield ,
James Spencer
Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition
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James Spencer,
Jürgen Brem ,
Christopher J. Schofield
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Jürgen Brem ,
Philip Hinchliffe ,
Karina Calvopiña,
Tharindi D. Panduwawala,
Pauline A. Lang ,
Jos J. A. G. Kamps,
Jonathan M. Tyrrell,
Emma Widlake,
Benjamin G. Saward,
Timothy R. Walsh,
James Spencer ,
Christopher J. Schofield
Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases
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