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Royal Society of Chemistry, Chemical Science, 26(14), p. 7262-7278, 2023

DOI: 10.1039/d2sc06858c

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High-throughput screen with the l,d-transpeptidase Ldt<sub>Mt2</sub> of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors

Journal article published in 2023 by Mariska de Munnik ORCID, Pauline A. Lang ORCID, Francisco De Dios Anton, Mónica Cacho ORCID, Robert H. Bates ORCID, Jürgen Brem ORCID, Beatriz Rodríguez Miquel ORCID, Christopher J. Schofield ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

10 000 electrophilic compounds were screened for inhibition of the essential l,d-transpeptidase (LdtMt2) of Mycobacterium tuberculosis. Potent covalently reacting inhibitors were identified and characterised by protein X-ray and MS studies.