Published in
Royal Society of Chemistry, RSC Chemical Biology, 3(4), p. 235-243, 2023
DOI: 10.1039/d2cb00182a
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Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66
Journal article published in 2023 by
Vildan A. Türkmen,
Jordi C. J. Hintzen 
,
Anthony Tumber,
Laust Moesgaard,
Eidarus Salah,
Jacob Kongsted ,
Christopher J. Schofield ,
Jasmin Mecinović
,
Anthony Tumber,
Laust Moesgaard,
Eidarus Salah,
Jacob Kongsted ,
Christopher J. Schofield ,
Jasmin Mecinović
This paper is made freely available by the publisher.
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Abstract
Ribosomal histidine hydroxylases MINA53 and NO66 exhibit narrow substrate selectivities for ribosomal protein L27a/L8 peptides possessing histidine analogues. Selected Rpl peptides display potent inhibition against MINA53 and NO66, providing a basis for inhibitor design.