All papers authored by Christopher Schofield
Refreshing results…
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B. Christoffer Lagerholm,
Lucy R. Henderson ,
Malitha Ratnaweera ,
Hannah T. Baddock,
Blanka Sengerova ,
Sook Lee,
Abimael Cruz-Migoni ,
Dominic Waithe,
Christian Renz ,
Helle D. Ulrich ,
Joseph A. Newman ,
Christopher J. Schofield ,
Peter J. McHugh
SNM1A is crucial for efficient repair of complex DNA breaks in human cells
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Shobhit S. Chaturvedi ,
Koteswara Rao Gorantla ,
Walter White,
Jon Wildey,
Christopher J. Schofield ,
Christo Z. Christov
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Nadia Saffoon,
John Walsby-Tickle ,
Svenja S. Hester,
Felix A. Dingler ,
Christopher L. Millington,
James S. O. McCullagh,
Ketan J. Patel,
Richard J. Hopkinson ,
Christopher J. Schofield
Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism
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Samuel C. Hoffman ,
C. David Owen,
C. David Owen ,
Petra Lukacik ,
Claire Strain-Damerell ,
Daren Fearon ,
Tika R. Malla,
Anthony Tumber,
Christopher J. Schofield ,
Helen M. E. Duyvesteyn ,
Wanwisa Dejnirattisai,
Loic Carrique ,
Thomas S. Walter ,
Gavin R. Screaton
and 6 other authors
Accelerating drug target inhibitor discovery with a deep generative foundation model
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Philip Hinchliffe ,
Michael Beer ,
Kirill Zinovjev ,
Charlotte K. Colenso,
Christopher J. Schofield ,
Adrian J. Mulholland ,
James Spencer
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Pauline A. Lang ,
Francisco De Dios Anton,
Mónica Cacho ,
Robert H. Bates ,
Jürgen Brem ,
Beatriz Rodríguez Miquel ,
Christopher J. Schofield
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Anthony Tumber,
Laust Moesgaard,
Eidarus Salah,
Jacob Kongsted ,
Christopher J. Schofield ,
Jasmin Mecinović
Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66
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Jeremy Nugent,
Bethany R. Shire,
Helena D. Pickford ,
Patrick Rabe ,
Alistair J. Sterling,
Tryfon Zarganes-Tzitzikas,
Thomas Grimes,
Amber L. Thompson ,
Russell C. Smith,
Christopher J. Schofield ,
Paul E. Brennan,
Fernanda Duarte ,
Edward A. Anderson
Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane
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Simahudeen Bathir Jaber Sathik Rifayee ,
Sodiq O. Waheed ,
Jon Wildey,
Cait Warner,
Christopher J. Schofield ,
Tatyana G. Karabencheva-Christova ,
Christo Z. Christov
Download from pubs.acs.org
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Ritu Raj,
Anthony Tumber,
Christopher T. Lohans ,
Patrick Rabe ,
Carol V. Robinson ,
Jürgen Brem,
Christopher J. Schofield
Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors
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Jürgen Brem ,
Michael A. McDonough,
James Spencer,
Christopher J. Schofield
Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2
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Mariliza Derveni,
Edward Wright,
Lester Marrison,
Alpha A. Lee ,
Aaron Morris,
Matt Robinson,
Frank von Delft,
Daren Fearon ,
Lizbé Koekemoer ,
Tetiana Matviuk
and 8 other authors
Expanding the Repertoire of Low‐Molecular‐Weight Pentafluorosulfanyl‐Substituted Scaffolds
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Tharindi Panduwawala ,
Jon Ulf Hansen,
Joanne Hewitt,
Edgars Liepins,
Pawel Donets ,
Laura Espina,
Alistair J. M. Farley,
Kirill Shubin,
Gonzalo Gomez Campillos ,
Paula Kiuru ,
Shifali Shishodia ,
Daniel Krahn,
Robert K. Leśniak,
Juliane Schmidt
and 46 other authors
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors
Download from www.nature.com
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Caitlin Clunie-O’Connor,
Anthony Tumber,
Ivanhoe K. H. Leung ,
Yi Min Ng,
Thomas M. Leissing,
Afaf H. El-Sagheer ,
Eidarus Salah,
Tom Brown ,
Wei Shen Aik,
Michael A. McDonough
and 1 other authors
Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors
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Jos J. A. G. Kamps ,
Kyle D. Sutherlin ,
James D. S. Linyard,
Pierre Aller,
Cindy C. Pham,
Hiroki Makita,
Ian Clifton ,
Michael A. McDonough,
Thomas M. Leissing,
Denis Shutin,
Pauline A. Lang ,
Agata Butryn,
Jürgen Brem ,
Sheraz Gul
and 26 other authors
X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis
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Philipp S. Simon ,
Pierre Aller ,
Philip Hinchliffe ,
Ramzi N. Massad,
Gabriel Leen,
Catherine L. Tooke ,
Isabel Bogacz,
In-Sik Kim,
Asmit Bhowmick,
Aaron S. Brewster ,
Nicholas E. Devenish,
Jürgen Brem ,
Jos J. A. G. Kamps ,
Pauline A. Lang
and 21 other authors
An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography
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Tika R. Malla,
Catherine L. Tooke ,
Jürgen Brem,
Karina Calvopiña,
Christopher T. Lohans,
Patrick Rabe,
Michael A. McDonough ,
Timothy Armistead,
Allen M. Orville ,
James Spencer ,
Christopher J. Schofield
Faropenem reacts with serine and metallo-β-lactamases to give multiple products
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Anthony Tumber ,
Tobias John ,
Lennart Brewitz ,
Claire Strain-Damerell ,
C. David Owen,
C. David Owen ,
Petra Lukacik ,
H. T. Henry Chan ,
H. T. Henry Chan,
Pratheesh Maheswaran ,
Eidarus Salah,
Fernanda Duarte ,
Haitao Yang,
Zihe Rao
and 2 other authors
Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors
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Philip Hinchliffe ,
Robert A. Bonomo ,
Christopher J. Schofield ,
Adrian J. Mulholland ,
James Spencer
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