Published in
Royal Society of Chemistry, Inorganic Chemistry Frontiers, 13(9), p. 3295-3305, 2022
DOI: 10.1039/d2qi00778a
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Pt(ii) complex containing the 1R,2R enantiomer of trans-1,2-diamino-4-cyclohexene ligand effectively and selectively inhibits the viability of aggressive pancreatic adenocarcinoma cells and alters their lipid metabolism
Journal article published in 2022 by
Vojtech Novohradsky 
,
Lenka Markova ,
Hana Kostrhunova ,
Marie Svitelova,
Jana Kasparkova ,
Alessandra Barbanente,
Paride Papadia ,
Nicola Margiotta ,
James D. Hoeschele,
Viktor Brabec
,
Lenka Markova ,
Hana Kostrhunova ,
Marie Svitelova,
Jana Kasparkova ,
Alessandra Barbanente,
Paride Papadia ,
Nicola Margiotta ,
James D. Hoeschele,
Viktor Brabec
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Abstract
New compounds structurally derived from oxaliplatin exhibit high potency in malignant pancreatic adenocarcinoma cells. Their mechanism of antiproliferative action in pancreatic cancer cells involves inhibition of de novo lipid synthesis.