David R. Langley
0000-0002-0820-3190
Arvinas Inc
83 papers found
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Biochemical and Genetic Characterizations of a Novel Human Immunodeficiency Virus Type 1 Inhibitor That Blocks gp120-CD4 Interactions
Selective Interactions of Cationic Porphyrins with G-Quadruplex Structures
Molecular Dynamic Simulations of Environment and Sequence Dependent DNA Conformations: The Development of the BMS Nucleic Acid Force Field and Comparison with Experimental Results
Diastereoselective addition of Grignard reagents to azetidine-2,3-dione: Synthesis of novel Taxol® analogues
The synthesis and biological activity of enediyne minor groove binding hybrids
Synthesis of etoposide phosphate, BMY-40481: A water-soluble clinically active prodrug of etoposide
Isolation, Structure Determination, and Proposed Mechanism of Action for Artifacts of Maduropeptin Chromophore
Sequential 1H, 13C, and 15N-NMR Assignments and Solution Conformation of Apokedarcidin
Synthesis and antitumor properties of novel 14-β-hydroxytaxol and related analogues
Chemistry and structure elucidation of the kedarcidin chromophore. [Erratum to document cited in CA119(21):226387u]
Probing the Underlying Basis for the Binding Specificity of Calicheamicin γ1I. A Molecular Dynamics Study
The DNA-esperamicin A1 complex. A model based on solvated molecular dynamics simulations
Facile Synthesis of a Simplified Bicyclo[7.3.1] Esperamicin-Calicheamicin Enediyne Core
Chemistry and structure elucidation of the kedarcidin chromophore
The dynemicin-DNA intercalation complex: a model based on DNA affinity cleavage and molecular dynamics simulation
O-Debenzylation of a Pyrrolo[2,1-c][1,4]benzodiazepine in the Presence of a Carbinolamine Functionality: Synthesis of DC-81
Chemoselective synthesis of allyltrimethylsilanes by cross-coupling of vinyl triflates with tris((trimethylsilyl)methyl)aluminum catalyzed by palladium(0)
E-ring desoxy analogs of etoposide
Convergent approach to intermediates used for the synthesis of the enediyne structure of the esperamicins and calicheamicins
Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds
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