David R. Langley - Dissemin

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Papers authored by David R. Langley

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2024 Sheryl M. Gough

ORCID

, John J. Flanagan

ORCID

ORCID

, Monica Andreoli

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, Emma Rousseau

ORCID

, Melissa Pannone, Mark Bookbinder

ORCID

ORCID

, Kim Davenport

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, Elizabeth Bortolon

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, Gregory Cadelina

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, Deborah Gordon

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, Jennifer Pizzano

ORCID

, Jennifer Macaluso

ORCID

ORCID

and 15 other authors

Oral estrogen receptor PROTAC® vepdegestrant (ARV-471) is highly efficacious as monotherapy and in combination with CDK4/6 or PI3K/mTOR pathway inhibitors in preclinical ER+ breast cancer models

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2022 Miklós Békés

ORCID

, David R. Langley

ORCID

, Craig M. Crews

ORCID

PROTAC targeted protein degraders: the past is prologue

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Kyle Trainor, Colleen M. Doyle, Avril Metcalfe-Roach, Julia Steckner, Daša Lipovšek, Heather Malakian, David Langley

ORCID

, Stanley R. Krystek Jr., Elizabeth M. Meiering

Design for Solubility May Reveal Induction of Amide Hydrogen/Deuterium Exchange by Protein Self-Association

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2021 Prasanna Sivaprakasam

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, Ivar McDonald, Christiana Iwuagwu, Naidu S. Chowdari, Kevin M. Peese

ORCID

, David R. Langley

ORCID

ORCID

, Michael R. Luzung, Michael A. Schmidt

ORCID

ORCID

, Yichen Tan, Patricia Cho, Souvik Rakshit, Thirumalai Lakshminarasimhan, Sivakrishna Guturi and 16 other authors

DNA-Model-Based Design and Execution of Some Fused Benzodiazepine Hybrid Payloads for Antibody–Drug Conjugate Modality

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2020 Naidu S. Chowdari

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ORCID

, Ivar McDonald, Walter Johnson, David R. Langley

ORCID

, Prasanna Sivaprakasam, Robert Mate, Tram Huynh, Srikanth Kotapati

ORCID

, Madhura Deshpande, Chin Pan, Daniel Menezes, Yichong Wang, Chetana Rao, Ganapathy Sarma and 12 other authors

Design, Synthesis, and Structure–Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody–Drug Conjugates

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Prasanna Sivaprakasam, Zhongyu Wang, Nicholas A. Meanwell

ORCID

, Javed A. Khan, David R. Langley

ORCID

, Stephen R. Johnson, Guo Li, Annapurna Pendri, Timothy P. Connolly, Mian Gao, Daniel M. Camac, Cheryl Klakouski, Tatyana Zvyaga, Christopher Cianci, Brian McAuliffe and 6 other authors

Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase

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Guo Li, Nicholas A. Meanwell

ORCID

, Mark R. Krystal, David R. Langley

ORCID

, B. Narasimhulu Naidu, Prasanna Sivaprakasam, Hal Lewis, Kevin Kish, Javed A. Khan, Alicia Ng, George L. Trainor, Christopher Cianci, Ira B. Dicker, Michael A. Walker, Zeyu Lin and 5 other authors

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors

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Kevin M. Peese, B. Narasimhulu Naidu, Manoj Patel, Chen Li, David R. Langley

ORCID

, Brian Terry, Tricia Protack, Volodymyr Gali, Zeyu Lin, Himadri K. Samanta, Ming Zheng, Susan Jenkins, Ira B. Dicker, Mark R. Krystal, Nicholas A. Meanwell and 1 other authors

Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors

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2019 David Wensel, Yongnian Sun, Jonathan Davis, Zhufang Li, Sharon Zhang, Thomas McDonagh, David Langley

ORCID

, Tracy Mitchell, Sebastien Tabruyn, Patrick Nef, Mark Cockett, Mark Krystal

GSK3732394: a Multi-specific Inhibitor of HIV Entry

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Naidu S. Chowdari, Chin Pan, Chetana Rao, David R. Langley

ORCID

, Prasanna Sivaprakasam, Bilal Sufi, Daniel Derwin, Yichong Wang, Eilene Kwok, David Passmore, Vangipuram S. Rangan, Shrikant Deshpande, Pina Cardarelli, Gregory Vite, Sanjeev Gangwar

Uncialamycin as a novel payload for antibody drug conjugate (ADC) based targeted cancer therapy

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Yen-Ting Lai

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, Tao Wang, Sijy O’Dell, Mark K. Louder

ORCID

, Arne Schön, Crystal S. F. Cheung, Gwo-Yu Chuang, Aliaksandr Druz, Bob Lin, Krisha McKee, Dongjun Peng, Yongping Yang, Baoshan Zhang, Alon Herschhorn, Joseph Sodroski and 5 other authors

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

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2018 Justine N. deGruyter, Shengyang Ni, Alberto F. Garrido-Castro, Rohan R. Merchant, Justine N. de Gruyter, Daniel C. Schmitt, James J. Mousseau, Gary M. Gallego, Shouliang Yang, Michael R. Collins, Jennifer X. Qiao, Kap-Sun Yeung, David R. Langley

ORCID

, Michael A. Poss, Phil S. Baran

ORCID

and 2 other authors

A General Amino Acid Synthesis Enabled by Innate Radical Cross-Coupling

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Tao Wang

ORCID

, Yasu Ueda, Zhongxing Zhang, Zhiwei Yin, John Matiskella, Bradley C. Pearce, Zheng Yang, Ming Zheng, Dawn D. Parker, Gregory A. Yamanaka, Yi-Fei Gong, Hsu-Tso Ho, Richard J. Colonno, David R. Langley

ORCID

, Pin-Fang Lin and 2 other authors

Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir

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2017 Nicholas A. Meanwell

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, Mark R. Krystal, Beata Nowicka-Sans, David R. Langley

ORCID

, David A. Conlon

ORCID

, Martin D. Eastgate

ORCID

, Dennis M. Grasela, Peter Timmins

ORCID

, Tao Wang, John F. Kadow

Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir

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Marie Pancera, Yen-Ting Lai, Tatsiana Bylund, Aliaksandr Druz, Sandeep Narpala, Sijy O'Dell, Arne Schön, Robert T. Bailer, Gwo-Yu Chuang, Hui Geng, Mark K. Louder

ORCID

, Reda Rawi, Djade I. Soumana, Andrés Finzi, Alon Herschhorn and 7 other authors

Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529

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Ramkumar Rajamani, Sophie Wu, Iyoncy Rodrigo, Mian Gao, Simon Low, Lisa Megson, David Wensel, Rick L. Pieschl, Debra J. Post-Munson, John Watson, David R. Langley

ORCID

, Michael K. Ahlijanian, Linda J. Bristow, James Herrington

A Functional Na_V1.7-Na_VAb Chimera with a Reconstituted High-Affinity ProTx-II Binding Site

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2016 Guanglin Luo, Ling Chen, Catherine R. Burton, Hong Xiao, Prasanna Sivaprakasam, Carol M. Krause, Yang Cao, Nengyin Liu, Jonathan Lippy, Wendy J. Clarke, Kimberly Snow, Joseph Raybon, Vinod Arora, Matt Pokross, Kevin Kish and 4 other authors

Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors

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2015 Jin-Hua Sun, Donald R. O’Boyle Ii, Robert A. Fridell, David R. Langley

ORCID

, Chunfu Wang, Susan B. Roberts, Peter Nower, Benjamin M. Johnson, Frederic Moulin, Michelle J. Nophsker, Ying-Kai Wang, Mengping Liu, Karen Rigat, Yong Tu, Piyasena Hewawasam and 7 other authors

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A

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Prasanna Sivaprakasam, Xiaojun Han, Rita L. Civiello, Swanee Jacutin-Porte, Kevin Kish, Matt Pokross, Hal A. Lewis, Nazia Ahmed, Nicolas Szapiel, John A. Newitt, Eric T. Baldwin, Hong Xiao, Carol M. Krause, Hyunsoo Park, Michelle Nophsker and 5 other authors

Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core

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2014 David R. Langley

ORCID

, S. Roy Kimura, Prasanna Sivaprakasam, Nannan Zhou, Ira Dicker, Brian McAuliffe, Tao Wang, John F. Kadow, Nicholas A. Meanwell, Mark Krystal

Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action

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