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All papers authored by Aaron Smith

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2022 Giuditta Illuzzi

ORCID

, Anna D. Staniszewska

ORCID

, Sonja J. Gill

ORCID

ORCID

, Lisa McWilliams

ORCID

, Susan E. Critchlow

ORCID

ORCID

, Stephen Fawell

ORCID

, Glen Hawthorne

ORCID

ORCID

, Jeffrey Johannes

ORCID

, Emilyanne Leonard

ORCID

, Ruth Macdonald

ORCID

, Gareth Maglennon

ORCID

, Jenni Nikkilä

ORCID

and 7 other authors

Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper

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2021 Tudor Petreus, Elaine Cadogan

ORCID

, Gareth Hughes, Aaron Smith

ORCID

, Venkatesh Pilla Reddy, Alan Lau, Mark James O’Connor, Susan Critchlow, Marianne Ashford

ORCID

, Lenka Oplustil O’Connor

ORCID

Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response

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Balakrishna Koneru, Ahsan Farooqi, Thinhh H. Nguyen, Wan Hsi Chen, Ashly Hindle, Cody Eslinger, Monish Ram Makena, Trevor A. Burrow, Joanne Wilson, Aaron Smith

ORCID

, Venkatesh Pilla Reddy, Elaine Cadogan, Stephen T. Durant, C. Patrick Reynolds

ALT Neuroblastoma Chemoresistance due to ATM Activation by Telomere Dysfunction is Reversible with the ATM Inhibitor AZD0156

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2020 Lucy C. Riches, Antonio G. Trinidad, Gareth Hughes

ORCID

, Gemma N. Jones, Adina M. Hughes

ORCID

, Andrew G. Thomason

ORCID

, Paul Gavine, Andy Cui

ORCID

, Stephanie Ling, Jonathan Stott, Roger Clark, Samantha Peel, Pendeep Gill, Louise M. Goodwin, Aaron Smith

ORCID

and 6 other authors

Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically

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2019 Jacqueline H. L. Fok, Antonio Ramos-Montoya

ORCID

, Mercedes Vazquez-Chantada, Paul W. G. Wijnhoven, Valeria Follia, Neil James, Paul M. Farrington, Ankur Karmokar, Sophie E. Willis

ORCID

, Jonathan Cairns, Jenni Nikkilä, David Beattie, Gillian M. Lamont, M. Raymond V. Finlay

ORCID

, Joanne Wilson and 10 other authors

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

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Chiara Fornari, Lenka Oplustil O'Connor, Carmen Pin, Aaron Smith

ORCID

, James W. T. Yates, S. Y. Amy Cheung, Duncan I. Jodrell, Jerome T. Mettetal, Teresa A. Collins

Quantifying Drug‐Induced Bone Marrow Toxicity Using a Novel Haematopoiesis Systems Pharmacology Model

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2018 Jason G. Kettle

ORCID

, Rana Anjum, Evan Barry, Deepa Bhavsar, Crystal Brown, Scott Boyd, Andrew Campbell, Kristin Goldberg, Michael Grondine, Sylvie Guichard, Christopher J. Hardy, Tom Hunt, Rhys D. O. Jones, Xiuwei Li, Olga Moleva and 12 other authors

Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors

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Stephen T. Durant

ORCID

, Li Zheng

ORCID

, Yingchun Wang, Kan Chen, Lingli Zhang, Tianwei Zhang, Zhenfan Yang, Lucy Riches, Antonio G. Trinidad, Jacqueline H. L. Fok

ORCID

, Tom Hunt

ORCID

, Kurt G. Pike, Joanne Wilson, Aaron Smith

ORCID

, Nicola Colclough and 23 other authors

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models

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Jeremy Karlin, Jasmine Allen, Syed F. Ahmad, Gareth Hughes, Victoria Sheridan, Rajesh Odedra, Paul Farrington, Elaine B. Cadogan, Lucy C. Riches, Antonio Garcia-Trinidad, Andrew G. Thomason, Bhavika Patel, Jennifer Vincent, Alan Lau, Kurt G. Pike and 21 other authors

Orally Bioavailable and Blood–Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice

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Didier Decaudin, Rania El Botty, Rania El Botty

ORCID

, Béré Diallo, Gerald Massonnet, Justine Fleury, Adnan Naguez, Chloé Raymondie, Emma Davies, Aaron Smith

ORCID

, Joanne Wilson, Colin Howes, Paul D. Smit, Paul D. Smith, Nathalie Cassoux and 3 other authors

Selumetinib-based therapy in uveal melanoma patient-derived xenografts

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2017 Justin Greene, Anna Nguyen, Stacey M. Bagby, Gemma N. Jones, W.-M. Tai, Kevin S. Quackenbush, Anna Schreiber, Wells A. Messersmith, Kalpana M. Devaraj, Patrick Blatchford, S. Gail Eckhardt, Elaine B. Cadogan, Gareth D. Hughes, Aaron Smith

ORCID

, Todd M. Pitts and 1 other authors

The novel ATM inhibitor (AZ31) enhances antitumor activity in patient derived xenografts that are resistant to irinotecan monotherapy

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Weiyi Toy, Hazel Weir, Pedram Razavi, Mandy Lawson, Anne U. Goeppert, Anne Marie Mazzola, Aaron Smith

ORCID

, Joanne Wilson, Christopher Morrow, Wai Lin Wong, Elisa De Stanchina, Kathryn E. Carlson, Teresa S. Martin, Sharmeen Uddin, Zhiqiang Li and 5 other authors

Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists

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Richard M. England, Jennifer I. Hare, Jennifer Barnes, Joanne Wilson, Aaron Smith

ORCID

, Nicole Strittmatter

ORCID

, Paul D. Kemmitt, Michael J. Waring

ORCID

, Simon T. Barry, Cameron Alexander, Marianne B. Ashford

Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers

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2016 Susan Ashton, Young Ho Song, Jim Nolan, Elaine Cadogan, Jim Murray, Rajesh Odedra, John Foster, Peter A. Hall, Susan Low, Paula Taylor, Rebecca Ellston, Urszula M. Polanska, Joanne Wilson, Colin Howes, Aaron Smith

ORCID

and 17 other authors

Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo

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2015 Alwin G. Schuller, Evan R. Barry, Rhys Do O. Jones, Ryan E. Henry, Melanie M. Frigault, Garry Beran, David Linsenmayer, Michael Zinda, Maureen Mertens Hattersley, Stefano Cairo

ORCID

, Aaron Smith

ORCID

, Olivier Deas, Delphine Nicolle, Joanne Wilson, Ammar Adam and 4 other authors

The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models

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2010 Stuart W. Paine, Patrick Barton, James Bird, Rebecca Denton, Karelle Menochet, Aaron Smith

ORCID

, Nicholas P. Tomkinson, Kamaldeep K. Chohan

A rapid computational filter for predicting the rate of human renal clearance

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