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All papers authored by Wenchao Lu

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2023 Suman Mukhopadhyay

ORCID

, Hsin-Yi Huang

ORCID

ORCID

, Michela Ranieri

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, Shuai Li

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, Soumyadip Sahu

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ORCID

, Yi Ban

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, Hai Hu

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, Alfonso Lopez

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, Fiona Sherman

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, Yeuan Ting Lee

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, Amanda P. Armstrong

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and 11 other authors

Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy

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Wenchao Lu

ORCID

ORCID

, Wenzhi Ji, Jason Tse, Inchul You, Scott B. Ficarro, Isidoro Tavares, Jianwei Che, Audrey Y. Kim, Xijun Zhu, Andrew Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Stephen M. Hinshaw

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and 6 other authors

Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors

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2022 Mengyang Fan

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, Wenchao Lu

ORCID

, Jianwei Che, Nicholas P. Kwiatkowski, Yang Gao, Hyuk-Soo Seo, Scott B. Ficarro, Prafulla C. Gokhale, Yao Liu, Ezekiel A. Geffken, Jimit Lakhani, Kijun Song

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, Miljan Kuljanin, Wenzhi Ji, Jie Jiang

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and 11 other authors

Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling

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Haibo Lu, Tian Lu, Shijia Zu, Zhe Duan, Yiman Guang, Qi Li, Jingyi Ma, Dongying Chen, Bo Li, Wenchao Lu

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, Hualiang Jiang, Cheng Luo, Deyong Ye, Kaixian Chen, Hua Lin

Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold

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2021 Tian Lu, Yong Li, Wenchao Lu

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, Twgm Spitters, Xueyu Fang, Jun Wang, Simian Cai

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, Jing Gao, Yanting Zhou, Zhe Duan, Huan Xiong, Liping Liu, Qi Li, Hualiang Jiang, Kaixian Chen and 6 other authors

Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3

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Tian Lu, Haibo Lu, Zhe Duan, Jun Wang, Jie Han, Senhao Xiao, HuanHuan Chen, Hao Jiang, Yu Chen, Feng Yang, Qi Li, Dongying Chen, Jin Lin, Bo Li

ORCID

, Hualiang Jiang and 4 other authors

Discovery of High-Affinity Inhibitors of the BPTF Bromodomain

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Guangyan Du, Jie Jiang, Qibiao Wu, Nathaniel J. Henning, Katherine A. Donovan, Hong Yue, Jianwei Che, Wenchao Lu

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, Eric S. Fischer, Nabeel Bardeesy, Tinghu Zhang, Nathanael S. Gray

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Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2

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Baishan Jiang

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, Yang Gao, Jianwei Che

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, Wenchao Lu

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, Ines H. Kaltheuner, Ruben Dries

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, Marian Kalocsay

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, Matthew J. Berberich, Jie Jiang, Inchul You, Nicholas Kwiatkowski, Kristin M. Riching, Danette L. Daniels

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, Peter K. Sorger

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, Matthias Geyer and 2 other authors

Discovery and resistance mechanism of a selective CDK12 degrader

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Wenchao Lu

ORCID

, Milka Kostic, Tinghu Zhang, Jianwei Che, Matthew P. Patricelli, Lyn H. Jones, Edward T. Chouchani, Nathanael S. Gray

Correction: Fragment-based covalent ligand discovery

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Wenchao Lu

ORCID

ORCID

, Tinghu Zhang, Jianwei Che, Matthew P. Patricelli, Lyn H. Jones

ORCID

, Edward T. Chouchani, Nathanael S. Gray

ORCID

Fragment-based covalent ligand discovery

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2020 Yu Chen, Xiaoyang Bi, Fengcai Zhang, Zhongya Sun, Pan Xu, Hao Jiang, Wenchao Lu

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, Tian Lu, Hong Ding, Naixia Zhang, Hualiang Jiang, Kaixian Chen, Bing Zhou, Cheng Luo

Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain

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Xiaoyang Bi, Yu Chen, Zhongya Sun, Wenchao Lu

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, Pan Xu, Tian Lu, Hong Ding, Naixia Zhang, Hualiang Jiang, Kaixian Chen, Bing Zhou, Cheng Luo

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Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors

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Zhongya Sun, Hao Zhang, Yuanyuan Zhang, Liping Liao, Wen Zhou, Fengcai Zhang, Fulin Lian, Jing Huang, Pan Xu, Rukang Zhang, Wenchao Lu

ORCID

, Mingrui Zhu, Hongru Tao, Shijie Chen, Feng Yang and 12 other authors

Rho Family Proteins: Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion (Adv. Sci. 14/2020)

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Zhongya Sun, Hao Zhang, Yuanyuan Zhang, Liping Liao, Wen Zhou, Fengcai Zhang, Fulin Lian, Jing Huang, Pan Xu, Rukang Zhang, Wenchao Lu

ORCID

, Mingrui Zhu, Hongru Tao, Feng Yang, Hong Ding and 11 other authors

Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion

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Chengzhang Shi, Zhao Ye, Jie Han, Xiaoqing Ye, Wenchao Lu

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, Chenxing Ji, Zizhou Li, Zengyi Ma, Qilin Zhang, Yichao Zhang, Wenqiang He, Zhengyuan Chen, Xiaoyun Cao, Xuefei Shou, Xiang Zhou and 15 other authors

BRD4 as a therapeutic target for nonfunctioning and growth hormone pituitary adenoma

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2019 Tian Lu, Wenchao Lu

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, Cheng Luo

A patent review of BRD4 inhibitors (2013-2019)

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Wenchao Lu

ORCID

, Jun Wang, Yong Li, Hongru Tao, Huan Xiong, Fulin Lian, Jing Gao, Hongna Ma, Tian Lu, Dan Zhang, Xiaoqing Ye, Hong Ding, Liyan Yue, Yuanyuan Zhang, Huanyu Tang and 6 other authors

Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors

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Deheng Chen, Tian Lu, Ziqin Yan, Wenchao Lu

ORCID

, Feilong Zhou, Xilin Lyu, Biling Xu, Hualiang Jiang, Kaixian Chen, Cheng Luo

ORCID

ORCID

Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins

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Dan Zhang, Jie Han, Wenchao Lu

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, Fulin Lian, Jun Wang, Tian Lu, Hongru Tao, Senhao Xiao, Fengcai Zhang, Yu-Chih Liu, Rongfeng Liu, Naixia Zhang, Hualiang Jiang, Kaixian Chen, Chunshen Zhao and 1 other authors

Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening

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Xiaoqing Ye, Rukang Zhang, Fulin Lian, Weiyao Zhang, Wenchao Lu

ORCID

, Jie Han, Naixia Zhang, Jia Jin, Cheng Luo

ORCID

, Kaixian Chen, Fei Ye, Hong Ding

The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening

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