Stephen J. Haggarty - Dissemin

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All papers authored by Stephen J. Haggarty

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2021 Debasis Patnaik

ORCID

, Ping-Chieh Pao, Wen-Ning Zhao

ORCID

, M. Catarina Silva, Norma K. Hylton, Peter S. Chindavong, Ling Pan, Li-Huei Tsai, Stephen J. Haggarty

ORCID

Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration

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2020 Stephanie L. Saundh, Debasis Patnaik

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, Steve Gagné, Joshua A. Bishop, Sean Lipsit, Samat Amat, Narsimha Pujari, Anand Krishnan Nambisan, Robert Bigsby, Mary Murphy, Li-Huei Tsai, Stephen J. Haggarty

ORCID

, Adelaine Kwun-Wai Leung

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Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein

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M. Catarina Silva, Stephen J. Haggarty

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Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies

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Marina Kovalenko, Serkan Erdin

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, Marissa A. Andrew, Jason St Claire, Melissa Shaughnessey, Leroy Hubert, João Luís Neto

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, Alexei Stortchevoi, Daniel M. Fass

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, Ricardo Mouro Pinto, Stephen J. Haggarty

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, John H. Wilson, Michael E. Talkowski, Vanessa C. Wheeler

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Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice

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M. Catarina Silva

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, Ghata A. Nandi

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, Sharon Tentarelli, Ian K. Gurrell, Tanguy Jamier, Diane Lucente, Bradford C. Dickerson, Dean G. Brown, Nicholas J. Brandon, Stephen J. Haggarty

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Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

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Ping-Chieh Pao

ORCID

, Debasis Patnaik

ORCID

, L. Ashley Watson, Fan Gao, Ling Pan, Jun Wang, Chinnakkaruppan Adaikkan, Jay Penney, Hugh P. Cam, Wen-Chin Huang, Lorena Pantano

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, Audrey Lee, Alexi Nott

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, Trongha X. Phan, Elizabeta Gjoneska and 3 other authors

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

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2019 Josefa Zaldivar-Diez, Lingling Li, Ana M. Garcia, Wen-Ning Zhao

ORCID

, Cristina Medina-Menendez, Stephen J. Haggarty

ORCID

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, Aixa V. Morales, Ana Martinez

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Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate

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Vadim Bernard-Gauthier, Andrew V. Mossine, Ashley Knight

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, Debasis Patnaik

ORCID

, Wen-Ning Zhao

ORCID

, Chialin Cheng, Hema S. Krishnan, Lucius L. Xuan, Peter S. Chindavong, Surya A. Reis, Jinshan Michael Chen, Xia Shao, Jenelle Stauff, Janna Arteaga, Phillip Sherman and 12 other authors

Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery

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Carlos Moreno-Yruela

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, Daniel M. Fass, Chialin Cheng, Joachim Herz

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, Christian A. Olsen

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, Stephen J. Haggarty

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Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression

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Israel Hernandez

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, Gabriel Luna, Jennifer N. Rauch, Surya A. Reis

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, Michel Giroux

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, Celeste M. Karch

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, Daniel Boctor, Youssef E. Sibih

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, Nadia J. Storm, Antonio Diaz, Susmita Kaushik

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, Cezary Zekanowski, Alexander A. Kang

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, Cassidy R. Hinman, Vesna Cerovac

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and 7 other authors

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

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This paper is made freely available by the publisher.

2018 Xudong Lin, Xin Duan, Claire Jacobs, Jeremy Ullmann, Chung-Yuen Chan, Siya Chen, Shuk-Han Cheng

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, Wen-Ning Zhao, Annapurna Poduri, Xin Wang

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, Stephen J. Haggarty

ORCID

, Peng Shi

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High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology

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Wen-Ning Zhao

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, Balaram Ghosh

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, Marshall Tyler

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, Jasmin Lalonde, Nadine F. Joseph, Nina Kosaric, Daniel M. Fass, Li-Huei Tsai, Ralph Mazitschek, Stephen J. Haggarty

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Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory

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2017 Jinsoo Seo, Oleg Kritskiy, L. Ashley Watson, Scarlett J. Barker, Dilip Dey, Waseem K. Raja, Yuan-Ta Lin, Tak Ko, Sukhee Cho, Jay Penney, M. Catarina Silva

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, Steven D. Sheridan

ORCID

, Diane Lucente, James F. Gusella, Bradford C. Dickerson

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and 2 other authors

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

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Begum Alural, Sermin Genc, Stephen J. Haggarty

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Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future

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2016 Emily L. Ricq, Jacob M. Hooker, Stephen J. Haggarty

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Activity-dependent Regulation of Histone Lysine Demethylase KDM1A by a Putative Thiol/Disulfide Switch

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Florence F. Wagner, Michel Weïwer, Stefan Steinbacher, Adrian Schomburg, Peter Reinemer, Jennifer P. Gale

ORCID

, Arthur J. Campbell, Stewart L. Fisher, Wen-Ning Zhao, Surya A. Reis, Krista M. Hennig, Méryl Thomas, Peter Müller, Martin R. Jefson, Daniel M. Fass and 3 other authors

Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors

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M. Catarina Silva, Chialin Cheng, Waltraud Mair, Sandra Almeida, Helen Fong, M. Helal U. U. Biswas, Zhijun Zhang, Yadong Huang, Sally Temple, Giovanni Coppola, Daniel H. Geschwind, Anna Karydas, Bruce L. Miller, Kenneth S. Kosik, Fen-Biao Gao and 2 other authors

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability

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Hsiao-Ying Wey, Tonya M. Gilbert, Nicole R. Zurcher, Angela She, Anisha Bhanot, Brendan D. Taillon, Fredrick A. Schroeder, Changing Wang, Stephen J. Haggarty

ORCID

, Jacob M. Hooker

Insights into neuroepigenetics through human histone deacetylase PET imaging

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M. J. Kim, J. Biag

ORCID

, D. M. Fass, M. C. Lewis, Q. Zhang, M. Fleishman, S. P. Gangwar, M. Machius, M. Fromer, S. M. Purcell, S. A. McCarroll, G. Rudenko, R. T. Premont, E. M. Scolnick, S. J. Haggarty

ORCID

Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1–PAK3 signaling in neuroplasticity

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