Published in
Royal Society of Chemistry, Chemical Communications, 95(48), p. 11623
DOI: 10.1039/c2cc36610j
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Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications
Journal article published in 2012 by
Chiara Gabbiani 
,
Federica Scaletti,
Lara Massai,
Elena Michelucci,
Maria Agostina Cinellu,
Luigi Messori
,
Federica Scaletti,
Lara Massai,
Elena Michelucci,
Maria Agostina Cinellu,
Luigi Messori
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Abstract
Based on ESI-MS measurements, we show here that some representative cytotoxic gold(III) compounds produce stable adducts upon reaction with the copper chaperone Atox-1; notably, such adducts contain gold in the oxidation state +1. These findings are of interest to understand the intracellular metabolism of medicinal gold species and to develop new potent inhibitors of the copper trafficking system.