Published in
American Association for the Advancement of Science, Science Signaling, 488(10), 2017
DOI: 10.1126/scisignal.aaf2969
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PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity
Journal article published in 2017 by
Ludovic Breasson 
,
Barbara Becattini ,
Claudia Sardi,
Angela Molinaro ,
Fabio Zani ,
Romina Marone ,
Fabrizio Botindari ,
Mélanie Bousquenaud,
Curzio Ruegg,
Matthias P. Wymann ,
Giovanni Solinas
,
Barbara Becattini ,
Claudia Sardi,
Angela Molinaro ,
Fabio Zani ,
Romina Marone ,
Fabrizio Botindari ,
Mélanie Bousquenaud,
Curzio Ruegg,
Matthias P. Wymann ,
Giovanni Solinas
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Abstract
The kinase PI3Kγ aggravates obesity by activating macrophages and triggering inflammation in adipose tissue.