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Royal Society of Chemistry, MedChemComm, 7(8), p. 1553-1560

DOI: 10.1039/c7md00230k

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Structure–metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines

Journal article published in 2017 by Sabin Llona-Minguez ORCID, Artin Ghassemian, Pawel Baranczewski, Matthieu Desroses ORCID, Tobias Koolmeister, Per Artursson, Martin Scobie, Thomas Helleday ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

In this study, we provide insight into the metabolic profile of a series of piperazin-1-ylpyridazines suffering from rapid in vitro intrinsic clearance in a metabolic stability assay using liver microsomes.