Published in
Royal Society of Chemistry, MedChemComm, 3(9), p. 576-582
DOI: 10.1039/c7md00629b
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Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and α1 receptor antagonists
Journal article published in 2018 by
Hui Li Heng 
,
Chin Fei Chee ,
Sek Peng Chin ,
Yifan Ouyang,
Hao Wang,
Michael J. C. Buckle ,
Deron R. Herr ,
Ian C. Paterson ,
Stephen W. Doughty ,
Noorsaadah A.-B.-D. Rahman ,
Lip Yong Chung
,
Chin Fei Chee ,
Sek Peng Chin ,
Yifan Ouyang,
Hao Wang,
Michael J. C. Buckle ,
Deron R. Herr ,
Ian C. Paterson ,
Stephen W. Doughty ,
Noorsaadah A.-B.-D. Rahman ,
Lip Yong Chung
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Abstract
(R)-roemerine was found to be a potent 5-HT2A/C receptor antagonist with good selectivity compared to 5-HT2B and α1 receptor subtypes.