Published in
Royal Society of Chemistry, Chemical Communications, 40(52), p. 6727-6730, 2016
DOI: 10.1039/c6cc00529b
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Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo
Journal article published in 2016 by
Sook Y. Lee,
Jürgen Brem 
,
Ilaria Pettinati,
Timothy D. W. Claridge,
Opher Gileadi,
Christopher J. Schofield,
Peter J. McHugh
,
Ilaria Pettinati,
Timothy D. W. Claridge,
Opher Gileadi,
Christopher J. Schofield,
Peter J. McHugh
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Abstract
The human metallo-β-lactamase fold DNA repair enzymes SNM1A and SNM1B can be inhibited by cephalosporin-family molecules, revealing a potential new strategy to chemosensitive tumours, as well as a novel evolutionary link.