Published in
Royal Society of Chemistry, Organic Chemistry Frontiers, 11(3), p. 1392-1415, 2016
DOI: 10.1039/c6qo00319b
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A new approach toward the synthesis of 2,4-bis(fluoroalkyl)-substituted quinoline derivatives using fluoroalkyl amino reagent chemistry
Journal article published in 2016 by
Fallia Aribi,
Etienne Schmitt,
Armen Panossian,
Jean-Pierre Vors,
Sergiy Pazenok,
Frédéric R. Leroux 
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Abstract
The present work describes the unprecedented use of Fluoroalkyl Amino Reagents (FARs) to afford 2,4-bis(fluoroalkyl)-substituted quinoline derivatives in two steps under mild reaction conditions, in good yields and with a very good regioselectivity.