Published in
Royal Society of Chemistry, Analyst, 15(142), p. 2836-2845, 2017
DOI: 10.1039/c7an00622e
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Reaction screening and optimization of continuous-flow atropine synthesis by preparative electrospray mass spectrometry
Journal article published in 2017 by
Caitlin E. Falcone,
Zinia Jaman,
Michael Wleklinski,
Andy Koswara,
David H. Thompson,
R. Graham Cooks 
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Abstract
Reaction mixtures are screened by droplet ES synthesis; optimum reagents and conditions as determined using MS analysis are then transferred to a microfluidic system. This rapid screening/optimization approach is applied to the synthesis of atropine.