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Royal Society of Chemistry, Chemical Communications, 14(53), p. 2268-2271

DOI: 10.1039/c6cc08492c



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A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging

Journal article published in 2017 by F. Doria ORCID, M. Nadai ORCID, M. Zuffo, R. Perrone ORCID, M. Freccero ORCID, S. N. Richter ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Aggregation, red-NIR emission and light-up upon nucleic acid G-quadruplex binding have been investigated for a prototype core-extended naphthalene diimide, which is capable of fast cellular entry and nucleolar localization. Both high-level colocalization with an anti-G-quadruplex antibody and nucleolin displacement reveal that the compound targets and thus makes visible nuclear DNA G-quadruplexes.