A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging

Journal article published in 2017 by F. DoriaORCID, M. NadaiORCID, M. Zuffo, R. PerroneORCID, M. FrecceroORCID, S. N. RichterORCID

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Publisher: Royal Society of Chemistry

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Aggregation, red-NIR emission and light-up upon nucleic acid G-quadruplex binding have been investigated for a prototype core-extended naphthalene diimide, which is capable of fast cellular entry and nucleolar localization. Both high-level colocalization with an anti-G-quadruplex antibody and nucleolin displacement reveal that the compound targets and thus makes visible nuclear DNA G-quadruplexes.