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Royal Society of Chemistry, Analytical Methods, 8(3), p. 1729, 2011

DOI: 10.1039/c1ay05107e

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Highlighting anatomical sub-structures in rat brain tissue using lipid imaging

Journal article published in 2011 by Alice M. Delvolve, Benoit Colsch ORCID, Amina S. Woods
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Cell membranes are made up of a mixture of glycerolipids, sphingolipids, gangliosides and cholesterol. Lipids play important roles in a cell’s life. However many of their functions have still to be discovered. In the present work, we describe an efficient, easy and rapid methodology to accurately localize phosphatidylcholines and sphingomyelins from a single coronal rat brain section in the cerebrum area. Matrix assisted laser desorption/ionization (MALDI) mass spectrometry was used to profile and image lipids. The best resolved structure was 25–50 μm in the hippocampus.