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Royal Society of Chemistry, Chemical Communications, 10(53), p. 1626-1629

DOI: 10.1039/c6cc08793k

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Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

Journal article published in 2017 by Arthur H. A. M. van Onzen, Arthur H. A. M. van Onzen, Lorenzo Albertazzi, Aphj Albert Schenning, Albertus P. H. J. Schenning, Lg Lech-Gustav Milroy, Luc Brunsveld ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The fate of small molecule nanoparticles (SMNPs) composed of self-assembling intrinsically fluorescent π-conjugated oligomers was studied in cells as a function of side-chain hydrophobicity. While the hydrophobic SMNPs remained intact upon cellular uptake, the more hydrophilic SMNPs disassembled and dispersed throughout the cytosol.