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Royal Society of Chemistry, Analyst, 11(139), p. 2714-2720, 2014

DOI: 10.1039/c4an00548a

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Touch Spray Mass Spectrometry for In Situ Analysis of Complex Samples

Journal article published in 2014 by Kevin S. Kerian, Alan K. Jarmusch, R. Graham Cooks ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Touch spray, a spray-based ambient in-situ ionization method, uses a small probe, e.g. a teasing needle to pick up sample and the application of voltage and solvent to cause field-induced droplet emission. Compounds extracted from the microsample are incorporated into the sprayed micro droplets. Performance tests include disease state of tissue, microorganism identification, and therapeutic drug quantitation. Chemical derivatization is performed simultaneously with ionization.