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Royal Society of Chemistry, Dalton Transactions, 10(41), p. 3001-3005, 2012

DOI: 10.1039/c2dt12024k

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Solid-phase synthesis of oxaliplatin–TAT peptide bioconjugates

Journal article published in 2012 by Sergey Abramkin, Seied M. Valiahdi, Michael A. Jakupec ORCID, Markus Galanski, Nils Metzler-Nolte, Bernhard K. Keppler
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Conjugation of a platinum(iv) analog of oxaliplatin to a TAT-peptide fragment as a vehicle for membrane penetration was accomplished; cytotoxicity of mono- and diconjugates revealed IC50 values in the low micromolar range.