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Royal Society of Chemistry, Organic and Biomolecular Chemistry

DOI: 10.1039/c6ob00332j

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Identification of an active metabolite of PAR-1 antagonist RWJ-58259 and synthesis of analogues to enhance its metabolic stability

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This paper is available in a repository.

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Abstract

Understanding the pharmacokinetic behaviour of PAR-1 antagonist RWJ-58259 and the synthesis of analogues to enhance metabolic stability.