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Royal Society of Chemistry, Chemical Communications, 84(52), p. 12454-12457

DOI: 10.1039/c6cc07110d

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Studies of G-quadruplexes formed within self-assembled DNA mini-circles

Journal article published in 2016 by Beata Klejevskaja, Alb Pyne, Matthew Reynolds, Arun Shivalingam, Richard Thorogate, Bw Hoogenboom, Liming Ying ORCID, Ramon Vilar ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We have developed self-assembled DNA mini-circles that contain a G-quadruplex-forming sequence from the c-Myc oncogene promoter and demonstrate by FRET that the G-quadruplex unfolding kinetics are 10-fold slower than for the simpler 24-mer G-quadruplex that is commonly used for FRET experiments.