Published in
Royal Society of Chemistry, Chemical Communications, 98(52), p. 14141-14144
DOI: 10.1039/c6cc08039a
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Molecular tweezers target a protein–protein interface and thereby modulate complex formation
Journal article published in 2016 by
F. Trusch 
,
K. Kowski,
K. Bravo-Rodriguez,
C. Beuck,
K. Breuck,
A. Sowislok,
B. Wettig,
A. Matena,
E. Sanchez Garcia,
H. Meyer,
T. Schrader,
P. Bayer
,
K. Kowski,
K. Bravo-Rodriguez,
C. Beuck,
K. Breuck,
A. Sowislok,
B. Wettig,
A. Matena,
E. Sanchez Garcia,
H. Meyer,
T. Schrader,
P. Bayer
This paper is made freely available by the publisher.
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Abstract
Molecular tweezers for lysine and arginine select a few residues on a protein surface and by their unique complexation mode disrupt a critical protein–protein interaction. Detailed structural information was gained by NMR experiments, strongly supported by QM/MM calculations and further substantiated by ITC, fluorescence anisotropy, ELISA and bio-layer-interference studies.