Using data from a study of Chinese immigrant religious institutions in New York City (primarily Christian and Buddhist), this paper explores why some religious institutions are more inclined than others to be involved in HIV-related work. Although numerous factors are likely to play a role, we focus on organisations’ differing views on social engagement as an explanatory factor. We hypothesise that religious institutions that value social engagement (‘civic’) will be more inclined towards HIV/AIDS involvement than those that are more inward focused (‘sanctuary’). Given that many religious institutions are fundamentally defined by their stance on the appropriateness of social engagement, better understanding of this key characteristic may help to inform community and government organisations aiming to increase religious institutions’ involvement in HIV/AIDS-related work. Our analysis suggests that some organisations may be less interested in taking on the challenges of working in HIV/AIDS because of their general view that churches or temples should not be socially engaged. On the other hand, religious institutions that have concerns about social acceptability, fear of infection or lack of capacity – but generally embrace social engagement – may be more open to partnering on HIV/AIDS-related work because of their overriding community service orientation.