Published in
Royal Society of Chemistry, MedChemComm, 4(6), p. 677-690, 2015
DOI: 10.1039/c4md00484a
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Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α<sub>1</sub>and 5-HT<sub>1A</sub>receptor ligand: an in vitro and computational study
Journal article published in 2015 by
Silvia Franchini 
,
Annamaria Baraldi,
Claudia Sorbi,
Federica Pellati,
Elena Cichero,
Umberto M. Battisti,
Piero Angeli,
Antonio Cilia,
Livio Brasili
,
Annamaria Baraldi,
Claudia Sorbi,
Federica Pellati,
Elena Cichero,
Umberto M. Battisti,
Piero Angeli,
Antonio Cilia,
Livio Brasili
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Abstract
Enantioseparation and stereoselective synthesis of (1), a potent 5-HT1AR ligand, were performed. Surprisingly, the enantiomers proved to be equipotent.