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Royal Society of Chemistry, MedChemComm, 11(6), p. 1954-1958
DOI: 10.1039/c5md00288e
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The first potent diphenyl phosphonate KLK4 inhibitors with unexpected binding kinetics
Journal article published in 2015 by
Jeroen van Soom,
Giuliana Cuzzucoli Crucitti,
Rafaela Gladysz,
Pieter van der Veken,
Roberto Di Santo 
,
Ingmar Stuyver,
Victoria Buck,
Anne-Marie Lambeir ,
Viktor Magdolen,
Jurgen Joossens,
Koen Augustyns
,
Ingmar Stuyver,
Victoria Buck,
Anne-Marie Lambeir ,
Viktor Magdolen,
Jurgen Joossens,
Koen Augustyns
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Abstract
We report the first highly potent and selective small-molecule KLK4 inhibitors, showing surprising reversible binding kinetics.