Published in
American Association for the Advancement of Science, Science Translational Medicine, 142(4), 2012
DOI: 10.1126/scitranslmed.3003989
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- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Reproducible quantification of cancer-associated proteins in body fluids using targeted proteomics
Journal article published in 2012 by
Ruth Hüttenhain 
,
Martin Soste,
Nathalie Selevsek,
Hannes Röst ,
Atul Sethi,
Christine Carapito ,
Terry Farrah,
Eric W. Deutsch ,
Ulrike Kusebauch,
Robert L. Moritz,
Emma Niméus-Malmström,
Oliver Rinner,
Ruedi Aebersold
,
Martin Soste,
Nathalie Selevsek,
Hannes Röst ,
Atul Sethi,
Christine Carapito ,
Terry Farrah,
Eric W. Deutsch ,
Ulrike Kusebauch,
Robert L. Moritz,
Emma Niméus-Malmström,
Oliver Rinner,
Ruedi Aebersold
This paper is available in a repository.
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Abstract
The rigorous testing of hypotheses on suitable sample cohorts is a major limitation in translational research. This is particularly the case for the validation of protein biomarkers where the lack of accurate, reproducible and sensitive assays for most proteins has precluded the systematic assessment of hundreds of potential marker proteins described in the literature.