Published in
Royal Society of Chemistry, Toxicology Research, 6(4), p. 1565-1577
DOI: 10.1039/c5tx00176e
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Quinoid derivatives of the nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine: activation pathway to amino acid adducts
Journal article published in 2015 by
Shrika G. Harjivan,
Pedro F. Pinheiro,
Inês L. Martins,
Ana L. Godinho,
Riccardo Wanke,
Pedro P. Santos,
Sofia A. Pereira,
Frederick A. Beland,
M. Matilde Marques 
,
Alexandra M. M. Antunes
,
Alexandra M. M. Antunes
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Abstract
Quinoid electrophiles from the nevirapine metabolites, 2-OH- and 3-OH-nevirapine, react with nitrogen-based bionucleophiles yielding covalent adducts.