Published in
Royal Society of Chemistry, Chemical Communications, 39(47), p. 11122, 2011
DOI: 10.1039/c1cc13854e
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Immobilized unfolded cytochrome c acts as a catalyst for dioxygen reduction
Journal article published in 2011 by
Claudio Tavagnacco,
Stefano Monari,
Antonio Ranieri,
Carlo Augusto Bortolotti 
,
Silvia Peressini,
Marco Borsari
,
Silvia Peressini,
Marco Borsari
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Abstract
Unfolding turns immobilized cytochrome c into a His–His ligated form endowed with catalytic activity towards O2, which is absent in the native protein. O2 could be used by naturally occurring unfolded cytochrome c as a substrate for the production of partially reduced oxygen species contributing to the cell oxidative stress.