Improvement of the pharmacological properties of amidated kyotorphin by means of iodination
Journal article published in 2016 by
Maria Cristina Oliveira 
,
Lurdes Gano ,
Isabel Santos,
João D. G. Correia ,
Isa D. Serrano,
Sónia Sá Santos,
Sónia Sá Santos,
Marta Ribeiro,
Juliana Perazzo,
Isaura Tavares,
Montserrat Heras,
Eduard Bardají,
Miguel A. R. B. Castanho
,
Lurdes Gano ,
Isabel Santos,
João D. G. Correia ,
Isa D. Serrano,
Sónia Sá Santos,
Sónia Sá Santos,
Marta Ribeiro,
Juliana Perazzo,
Isaura Tavares,
Montserrat Heras,
Eduard Bardají,
Miguel A. R. B. Castanho
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Abstract
Iodination resulted in a slow release-like process that converted KTP, a drug rapidly cleared and having a fast transient effect, into a pro drug having delayed and prolonged action.