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Royal Society of Chemistry, Organic and Biomolecular Chemistry, 9(14), p. 2698-2705, 2016

DOI: 10.1039/c5ob02110c

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Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Convergent-based synthesis of native IGF-II and two IGF-II analogues, with coumarin fluorescent probes incorporated at residues 19 and 28, and their use in FRET-based identification of interactions with the type 1 insulin-like growth factor receptor (IGF-IR).