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Royal Society of Chemistry, Organic and Biomolecular Chemistry, 9(14), p. 2698-2705, 2016

DOI: 10.1039/c5ob02110c

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Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R

Journal article published in 2016 by J. M. Cottam Jones, P. W. R. Harris, D. B. Scanlon, B. E. Forbes ORCID, M. A. Brimble, A. D. Abell
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Convergent-based synthesis of native IGF-II and two IGF-II analogues, with coumarin fluorescent probes incorporated at residues 19 and 28, and their use in FRET-based identification of interactions with the type 1 insulin-like growth factor receptor (IGF-IR).