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Royal Society of Chemistry, Molecular BioSystems, 10(11), p. 2750-2762

DOI: 10.1039/c5mb00385g

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Protein–protein interactions generate hidden feedback and feed-forward loops to trigger bistable switches, oscillations and biphasic dose–responses

Journal article published in 2015 by Thawfeek M. Varusai ORCID, Walter Kolch, Boris N. Kholodenko, Lan K. Nguyen
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Our work reveals that simple reversible protein–protein interactions, when embedded into signalling cascades, give rise to extremely rich and complex regulatory dynamics in the absence of explicit positive and negative feedbacks.