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Royal Society of Chemistry, Chemical Communications, 43(48), p. 5259, 2012

DOI: 10.1039/c2cc32013d

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Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors†

Journal article published in 2012 by Seth M. Cohen ORCID, David P. Martin
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A series of hydroxybenzoic acid derivatives have shown inhibitory activity against carbonic anhydrase (CA). X-ray crystallography shows that these molecules inhibit not by binding the active site metal ion but by strong hydrogen bonding to the metal-bound water nucleophile. The binding mode observed for these molecules is distinct when compared to other non-metal-binding CA inhibitors.