Published in
Royal Society of Chemistry, Analyst, 2(141), p. 579-584, 2016
DOI: 10.1039/c5an01763g
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Detection of DNA methyltransferase activity using allosteric molecular beacons
Journal article published in 2016 by
Weiting Zhang,
Xiaolong Zu,
Yanling Song,
Zhi Zhu 
,
Chaoyong James Yang
,
Chaoyong James Yang
This paper was not found in any repository, but could be made available legally by the author.
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Abstract
Abnormal DNA methylation patterns caused by altered DNA methyltransferase (MTase) activity are closely associated with cancer. Herein, using DNA adenine methylation methyltransferase (Dam MTase) as a model analyte, we designed an allosteric molecular beacon (aMB) for sensitive detection of Dam MTase activity.