Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 44(12), p. 8942-8946
DOI: 10.1039/c4ob01790k
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NIS-mediated oxidative cyclization of N-(2-trifluoromethyl-3-alkynyl) hydroxylamines: a facile access to 4-trifluoromethyl-5-acylisoxazoles
Journal article published in 2014 by
Li Zhang,
Qin Zeng,
Ao Mao,
Ziang Wu,
Tian Luo,
Yuanjing Xiao,
Junliang Zhang
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Abstract
A NIS mediated sequential procedure involving oxidation and electrophilic cycloisomerization ofN-(2-trifluoromethyl-3-alkynyl) hydroxylamines for 4-trifluoromethyl-5-acylisoxazole synthesis is developed.