Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 32(12), p. 6121
DOI: 10.1039/c4ob01142b
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Total synthesis of fluoxetine and duloxetine through an in situ imine formation/borylation/transimination and reduction approach
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Abstract
Efficient, catalytic, asymmetric total syntheses of both (R)-fluoxetine and (S)-duloxetine from α,β-unsaturated aldehydes are reported.