Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 20(12), p. 3181-3190, 2014
DOI: 10.1039/c4ob00150h
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“Click and go”: simple and fast folic acid conjugation
Journal article published in 2014 by
Alexandre F. Trindade 
,
Raquel F. M. Frade,
Ermelinda M. S. Maçôas,
Cátia Graça,
Catarina A. B. Rodrigues,
José M. G. Martinho ,
Carlos A. M. Afonso
,
Raquel F. M. Frade,
Ermelinda M. S. Maçôas,
Cátia Graça,
Catarina A. B. Rodrigues,
José M. G. Martinho ,
Carlos A. M. Afonso
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Abstract
A novel approach for conjugation of folic acid is presented allowing for its quantitative conjugation with several types of molecules (fluorescent probes) and materials (polymers and silica) based on strain-promoted alkyne–azide cycloaddition, without the need for expensive chromatographic purifcation.