Published in
Royal Society of Chemistry, MedChemComm, 3(5), p. 333
DOI: 10.1039/c3md00278k
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Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein
Journal article published in 2014 by
Daohong Liao,
Liming Sun,
Weilong Liu,
Sudan He,
Xiaodong Wang,
Xiaoguang Lei
This paper was not found in any repository, but could be made available legally by the author.
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Abstract
Through high-throughput screening of 200 000 compounds and subsequent structure–activity relationship (SAR) studies we identified necrosulfonamide (NSA) as a potent small molecule inhibitor for necroptosis, induced by a combination of TNF-a, Smac mimetic, and z-VAD-fmk (T/S/Z).