Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy
Journal article published in 2016 by
M. Broekgaarden,
R. van Vught,
S. Oliveira 
,
R. C. Roovers ,
P. M. P. van Bergen en Henegouwen,
R. J. Pieters,
T. M. Van Gulik,
E. Breukink,
Michal Heger
,
R. C. Roovers ,
P. M. P. van Bergen en Henegouwen,
R. J. Pieters,
T. M. Van Gulik,
E. Breukink,
Michal Heger
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Abstract
Photodynamic therapy for therapy-resistant cancers will greatly benefit from targeted delivery of tumor photosensitizing agents. In this study, a strategy for the site-specific conjugation of single domain antibodies onto liposomes containing the photosensitizer zinc phthalocyanine was developed and tested.