Published in
Royal Society of Chemistry, Chemical Communications, 28(52), p. 5045-5048, 2016
DOI: 10.1039/c6cc01744d
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Peptide based hydrogels for cancer drug release: Modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating D-amino acid residue(s)
Journal article published in 2016 by
Kingshuk Basu,
Abhishek Baral,
Shibaji Basak 
,
Ashkan Dehsorkhi,
Jayanta Nanda ,
Debmalya Bhunia,
Arindam Banerjee,
Surajit Ghosh,
Valeria Castelletto,
Ian W. Hamley
,
Ashkan Dehsorkhi,
Jayanta Nanda ,
Debmalya Bhunia,
Arindam Banerjee,
Surajit Ghosh,
Valeria Castelletto,
Ian W. Hamley
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Abstract
Synthetic tripeptide based noncytotoxic hydrogelators have been discovered for releasing an anticancer drug at physiological pH and temparature. Interestingly, gel stiffness, drug release capacity and proteolytic stability of these hydrogels has been sucessfully modulated by incorporating D-amino acid residues, indicating their potential use for drug delivery in future.