Royal Society of Chemistry, Dalton Transactions, 8(44), p. 3540-3543
DOI: 10.1039/c4dt02663b
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The DNA lesion 1,N6-ethenoadenine (εA) has been investigated with respect to its metal-binding properties. A synthetic DNA duplex comprising an εA:εA mispair readily forms doubly silver(I)-mediated base pairs εA–Ag(I)2–εA, representing the first example for a dinuclear metal-mediated homo base pair of a purine derivative. It also constitutes the first example for a Hoogsteen-type metal-mediated homo base pair within a B-DNA duplex.