Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Wingerden, S. van; Willer, Cristen J.; Speliotes, Elizabeth K.; Cj, Willer; Kl, Monda; Monda, Keri L.; Jackson, Anne U.; Lindgren, Cecilia M.; Thorleifsson, Gudmar; Berndt, Sonja I.; Randall, Joshua C.; Mägi, Reedik; Winkler, Thomas W.; Workalemahu, Tsegaselassie; Qi, Lu; Heid, Iris M.; Luan, Jian’an; Weedon, Michael N.; Allen, Hana Lango; Wood, Andrew R.; Stringham, Heather M.; Steinthorsdottir, Valgerdur; Wheeler, Eleanor; Weyant, Robert J.; Vedantam, Sailaja; Segré, Ayellet V.; Kk, Aben; Maegi, Reedik; Liang, Liming; Kilpelaenen, Tuomas O.; Park, Ju-Hyun; Mägi, Reedik; Ferreira, Teresa; Nemesh, James; Yang, Jian; Si, Berndt; Kilpeläinen, Tuomas O.; Kilpelanen, To; Toenjes, Anke; Johansson, Å.; Gustafsson, Stefan; Zhao, Jing Hua; Mf, Feitosa; Kutalik, Zoltán; Mr, Järvelin; Mangino, Massimo; Bouatia-Naji, Nabila; Welch, Ryan; Raychaudhuri, Soumya; Im, Heid; Smith, Albert Vernon; Scherag, Andre; Mt, Alibrandi; Ld, Atwood; Feitosa, Mary F.; Nl, Glazer; Yd, Chen; Heard-Costa, Nancy L.; Me, Goddard; Hottenga, Jouke-Jan; Hoesel, Volker; Mn, Cooper; Rn, Bergman; Amin, Najaf; Johnson, Toby; den Heijer, Martin; Ketkar, Shamika; Lamina, Claudia; To, Kilpeläinen; Fisher, Eva; Moffatt, Miriam F.; Li, Shengxu; Ll, Bonnycastle; Johansson, Åsa; Aben, Katja Kk H.; Sr, Bornstein; Myers, Richard H.; Estrada, Karol; Van Wingerden, S.; Absher, Devin M.; Watanabe, Richard M.; Nl, Heard Costa; van Wingerden, Sophie; White, Charles Cc; Mj, Brown; Perry, John R. B.; Dixon, Anna L.; Narisu, Narisu; Peters, Marjolein J.; Glazer, Nicole L.; Ta, Buchanan; Goddard, Michael E.; Konig, Inke R.; Jj, Hottenga; Preuss, Michael; Ripatti, Samuli; Esko, Tõnu; Rivadeneira, Fernando; Ps, Chines; Scott, Laura J.; Eestrada, K.; Sandholt, Camilla; Wiklund, Fredrik; Timpson, Nicholas J.; Tyrer, Jonathan P.; In, Day; Lango Allen, Hana; Mf, Moffatt; Mr, Erdos; Jo, Jansson; Jansson, John-Olov; Jg, Eriksson; Lawrence, Robert W.; Eesko, T.; Barlassina, Christina; Pellikka, Niina; Mf, Facheris; Prokopenko, Inga; Rh, Myers; Sb, Felix; Rw, Lawrence; Shi, Jianxin; Jorgensen, Torben; Lehtimaeki, Terho; Chasman, Daniel I.; Thiering, Elisabeth; Nb, Freimer; Koenig, Inke R.; Cooper, Matthew N.; Jh, Park; Alavere, Helene; Tönjes, Anke; Pv, Gejman; Almgren, Peter; Ida Chen, Y.-D.; Aspelund, Thor; Alibrandi, Maria T. S.; Wl, McArdle; Balkau, Beverley; Investigators, MAGIC (Meta-Analyses of Glucose and Insulin-Related Traits Consortium); Arnold, Alice M.; Ben-Shlomo, Yoav; Atwood, Larry D.; O'Donnell, Cj; Bergmann, Sven; Balmforth, Anthony J.; Heijer, Martin den; Biebermann, Heike; Bennett, Amanda J.; Bergman, Richard N.; Jr, Perry; Boes, Tanja; Ek, Speliotes; Blakemore, Alexandra I. F.; Busonero, Fabio; Mj, Peters; Bonnycastle, Lori Ll; Campbell, Harry; Bornstein, Stefan R.; Kb, Jacobs; Cavalcanti-Proença, Christine; Brown, Morris J.; Buchanan, Thomas A.; Clarke, Robert; Cappuccio, Francesco P.; Lm, Kaplan; Coin, Lachlan; Connell, John; Chen, Chih-Mei; Cm, Lindgren; Jw, Knowles; Chines, Peter S.; Duan, Jubao; Ir, König; Hm, Stringham; Au, Jackson; Day, Ian N. M.; König, Ir R.; Lj, Launer; Fischer-Posovszky, Pamela; Kusisto, J.; Friedrich, Nele; Jc, Randall; Ml, Lokki; Heath, Andrew C.; Fu, Mao; Mn, Weedon; Felix, Stephan B.; Hicks, Andrew Aa; Tw, Winkler; Facheris, Maurizio F.; Gaget, Stefan; Rn, Luben; Rj, Weyant; Hayward, Caroline; Folsom, Aaron R.; Platou, Carl G. P.; Hengstenberg, Christian; Gieger, Christian; Ng, Martin; Freimer, Nelson B.; Hinney, Anke; Jacobs, Kevin B.; Hofman, Albert; Goel, Anuj; Homuth, Georg; Goyette, Philippe; Jp, Beilby; Hui, Jennie; Gejman, Pablo V.; Elliott, Paul; Igl, Wilmar; Grallert, Harald; Geus, Eco J. C.; Elosua, Roberto; Iribarren, Carlos; Eiriksdottir, Gudny; Lj, Scott; Isomaa, Bo; Ma, Morken; Ebrahim, Shah; Gjesing, Anette P.; Gudnason, Vilmundur; Js, Beckmann; Jarick, Ivonne; Guiducci, Candace; Kaplan, Lee M.; Jewell, Elizabeth; Mj, Neville; John, Ulrich; Hassanali, Neelam; Js, Ngwa; Jørgensen, Torben; Jousilahti, Pekka; Jh, Zhao; Pietilaeinen, Kirsi H.; Jula, Antti; Gräßler, Jürgen; Knowles, Joshua W.; Kaakinen, Marika; Greenawalt, Danielle M.; Kajantie, Eero; Is, Farooqi; Mj, Caulfield; Groves, Christopher J.; Chen, Yii-Der Ida; Dm, Absher; Kathiresan, Sekar; Nj, Timpson; Pare, Guillaume; Kettunen, Johannes; Sj, Chanock; Kuusisto, Johanna; Kinnunen, Leena; Jp, Tyrer; Wh, Ouwehand; Hartikainen, Anna-Liisa; Kolcic, Ivana; Den Heijer, M.; Hall, Alistair S.; Rm, Watanabe; Koskinen, Seppo; Havulinna, Aki S.; Kovacs, Peter; Eebrahim, S.; La, Cupples; Launer, Lenore J.; Al, Dixon; Erdos, Michael R.; Kraft, Peter; Eriksson, Johan G.; Kvaløy, Kirsti; Laitinen, Jaana; Eelliott, P.; Lantieri, Olivier; Eelosua, R.; Lanzani, Chiara; Magic,; Kk, Ong; Eeiriksdottir, G.; Lecoeur, Cecile; Eerdos, M. R.; Lokki, Marja-Liisa; Hv, Huikuri; Lehtimäki, Terho; Lettre, Guillaume; Luben, Robert N.; Liu, Jianjun; Di, Chasman; van Meurs, Joyce B. Jb; van Ommen, Gert-Jan; Lorentzon, Mattias; Eeriksson, J. G.; Am, Arnold; Ludwig, Barbara; Tl, Assimes; Martin, Nicholas G.; Aj, Balmforth; Manunta, Paolo; Aj, Bennett; Ib, Borecki; König, Inke R.; Marek, Diana; Tb, Harris; McArdle, Wendy L.; Marre, Michel; Rb, Hayes; Ai, Blakemore; Av, Segrè; McCarthy, Anne; McKnight, Barbara; Meitinger, Thomas; Melander, Olle; Meyre, David; Montgomery, Grant W.; Morken, Mario A.; Kh, Pietiläinen; Midthjell, Kristian; Fp, Cappuccio; Morris, Andrew P.; Schunkeret, Heribert; Cm, Chen; O'Ddonnell, C. J.; Mr, Jarvelin; Ngwa, Julius S.; Ms, Nieminen; Mulic, Rosanda; Oostra, Ben; Ar, Wood; Neville, Matt J.; Kt, Khaw; Av, Smith; Nelis, Mari; La, Kiemeney; Nyholt, Dale R.; Ostra, B.; O'Rahilly, Stephen; Ong, Ken Kk; Ar, Folsom; Paré, Guillaume; Sephens, Jonathan; Tm, Frayling; Parker, Alex N.; Lc, Groop; Perola, Markus; Nw, Rayner; Pb, Munroe; Pichler, Irene; Ej, Geus; Pietiläinen, Kirsi H.; Sadaf Farooqi, I.; Polasek, Ozren; Platou, C. P.; Pouta, Anneli; Ap, Gjesing; Rafelt, Suzanne; Nr, Robertson; Raitakari, Olli; Lj, Palmer; Vogel, Carla I. G.; Rayner, Nigel W.; Magi, Reedik; Rc, Kaplan; Voight, Benjamin F.; Ridderstråle, Martin; Dm, Greenawalt; Rief, Winfried; Sa, McCarroll; Waite, Lindsay Ll; Cc, White; Ruokonen, Aimo; Walters, Gb Bragi; Robertson, Neil R.; O’donnell, Christopher J.; Rzehak, Peter; Salomaa, Veikko; Jn, Hirschhorn; Cj, Groves; Sanders, Alan R.; Kaehoenen, Mika; Wild, Sarah H.; Sandhu, Manjinder S.; Sanna, Serena; As, Hall; Saramies, Jouko; Ms, Sandhu; Kahonen, Mika; Witte, Daniel R.; Savolainen, Markku J.; Al, Hartikainen; Witteman, Jacqueline C.; Scherag, Susann; Gräßler, Jürgen; Schipf, Sabine; Schreiber, Stefan; Schunkert, Heribert; Mj, Savolainen; Viikari, Jorma; Silander, Kaisa; As, Havulinna; Visvikis-Siest, Sophie; Sinisalo, Juha; Siscovick, David S.; Vitart, Veronique; Smit, Jan H.; Mi, McCarthy; Soranzo, Nicole; Sovio, Ulla; Ac, Heath; Stephens, Jonathan; Swift, Amy J.; Surakka, Ida; Wallaschofski, Henri; Aa, Hicks; Jh, Smit; Tammesoo, Mari-Liis; Tardif, Jean-Claude; Widen, Elisabeth; Wiegand, Susanna; Teslovich, Tanya M.; Teder-Laving, Maris; Thompson, John R.; Willemsen, Gonneke; Ke, North; Thomson, Brian; Tönjes, Anke; Pm, Ridker; Tuomi, Tiinamaija; Xu, Jianfeng; Jb, van Meurs; Zhang, Qunyuan; Jr, O'Connell; Ml, Tammesoo; Vatin, Vincent; Zgaga, Lina; Jc, Tardif; Ziegler, Andreas; Van Meurs, J. B. J.; Tm, Teslovich; Zitting, Paavo; Procardis, Consortium; Jr, Thompson; van Duijn, Cornelia M.; Van OMen, G.-J.; Pp, Pramstaller; Mccarroll, Steven A.; Ll, Waite; Sh, Wild; Jc, Witteman; O’connell, Jeffrey R.; Huikuri, Heikki V.; Gw, Montgomery; Hebebrand, Johannes; James, Alan L.; Ap, Morris; Nj, Samani; McCarthy, Mark I.; Kähönen, Mika; Levinson, Douglas F.; Dr, Nyholt; Beilby, John P.; Macciardi, Fabio; Other, And; Nieminen, Markku S.; Ohlsson, Claes; An, Parker; Palmer, Lyle J.; Ridker, Paul M.; Pe, Schwarz; Cg, Platou; Stumvoll, Michael; Smith, Gd D.; Td, Spector; Di, Boomsma; Beckmann, Jacques S.; Boeing, Heiner; Ar, Sanders; Boerwinkle, Eric; FarOqi, I. S.; Fs, Collins; Caulfield, Mark J.; Graessler, Juergen; Tt, Valle; Chanock, Stephen J.; Ds, Siscovick; Collins, Francis S.; Farooqi, Is Sadaf; Nj, Wareham; Cupples, La Adrienne; Hu, Frank B.; Hall, Per; Heinrich, Joachim; Jarvelin, Marjo-Riitta; Gyllensten, Ulf; Hveem, Kristian; Wareham, Nicholas J.; Pm, Visscher; Khaw, Kay-Tee; Illig, Thomas; Wilson, James F.; Jf, Wilson; Hansen, Torben; Erdmann, Jeanette; Wright, Alan F.; Grönberg, Henrik; Froguel, Philippe; Zillikens, Mc Carola; Kiemeney, Lambertus A. L. M.; Kaprio, Jaakko; Aj, Swift; Karpe, Fredrik; Al, James; Lawlor, Debbie A.; Krude, Heiko; Visscher, Peter M.; Gj, van Ommen; Boomsma, Dorret I.; Harris, Tamara B.; BOmsma, D. I.; Mc, Zillikens; Hattersley, Andrew T.; Laakso, Markku; Munroe, Patricia B.; Hayes, Richard B.; Wabitsch, Martin; Df, Levinson; Metspalu, Andres; Ouwehand, Willem H.; Waeber, Gerard; At, Hattersley; He, Wichmann; Penninx, Brenda W.; Ci, Vogel; Pedersen, Oluf; Watkins, Hugh; Bf, Voight; Peters, Annette; Pramstaller, Peter Pp; Wichmann, He-Erich; Gb, Walters; Quertermous, Thomas; Fb, Hu; Reinehr, Thomas; Gronberg, Henrik; Rissanen, Aila; Dr, Witte; Rudan, Igor; Gr, Abecasis; Cs, Fox; Samani, Nilesh J.; Schwarz, Peter E. H.; Eerdmann, J.; Shuldiner, Alan R.; Spector, Timothy D. (Timothy David); Frogue, P.; O'Connell, Jeffrey R.; Tuomilehto, Jaakko; Da, Lawlor; Uda, Manuela; Gd, Smith; Uitterlinden, André; Valle, Timo Tt; Rj, Loos; Strachan, David P.; Bw, Penninx; McCarroll, Sa A.; O'ConneL,; SchleSinger, D.; Schadt, Eric Ee; Chatterjee, Nilanjan; Purcell, Shaun; P. Strachan, D. P.; Van Duijn, C.; Ar, Shuldiner; Schlessinger, David; I. McCarthy, Mark; Hunter, David J.; Dj, Hunter; StefanSon, K.; Assimes, Themistocles L.; Deloukas, Panos; Ingelsson, Erik; Kaplan, Robert C.; Borecki, Ingrid B.; Bragi Walters, G.; Mohlke, Karen L.; McArthy, M. I.; Fox, Caroline S.; Ee, Schadt; ChatterjE, N.; Haritunians, Talin; IngelSon, E.; Groop, Leif C.; Peltonen, Leena; Stefansson, Kari; Consortium, on behalf of Procardis; Greonberg, Henrik; Af, Wright; Thorsteinsdottir, Unnur; Dp, Strachan; Frayling, Timothy M.; North, Kari E.; Adreienne Cupples, L.; Davey Smith, George; Hirschhorn, Joel N.; Abecasis, Gonçalo R.; Barroso, Inês; Grönberg, Henrik; Carola Zillikens, M.; Boehnke, Michael; Loos, Ruth J. F.; Cm, van Duijn; Erich Wichmann, H.

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Jian Yang
Wingerden et al., 2010

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@article{Wingerden2010,
  abstract = {Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P &lt; 5 × 10⁻⁸), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.},
  author = {Wingerden, S. van and Willer, Cristen J. and Speliotes, Elizabeth K. and Cj, Willer and Kl, Monda and Monda, Keri L. and Jackson, Anne U. and Lindgren, Cecilia M. and Thorleifsson, Gudmar and Berndt, Sonja I. and Randall, Joshua C. and Mägi, Reedik and Winkler, Thomas W. and Workalemahu, Tsegaselassie and Qi, Lu and Heid, Iris M. and Luan, Jian’an and Weedon, Michael N. and Allen, Hana Lango and Wood, Andrew R. and Stringham, Heather M. and Steinthorsdottir, Valgerdur and Wheeler, Eleanor and Weyant, Robert J. and Vedantam, Sailaja and Segré, Ayellet V. and Kk, Aben and Maegi, Reedik and Liang, Liming and Kilpelaenen, Tuomas O. and Park, Ju-Hyun and Mägi, Reedik and Ferreira, Teresa and Nemesh, James and Yang, Jian and Si, Berndt and Kilpeläinen, Tuomas O. and Kilpelanen, To and Toenjes, Anke and Johansson, Å. and Gustafsson, Stefan and Zhao, Jing Hua and Mf, Feitosa and Kutalik, Zoltán and Mr, Järvelin and Mangino, Massimo and Bouatia-Naji, Nabila and Welch, Ryan and Raychaudhuri, Soumya and Im, Heid and Smith, Albert Vernon and Scherag, Andre and Mt, Alibrandi and Ld, Atwood and Feitosa, Mary F. and Nl, Glazer and Yd, Chen and Heard-Costa, Nancy L. and Me, Goddard and Hottenga, Jouke-Jan and Hoesel, Volker and Mn, Cooper and Rn, Bergman and Amin, Najaf and Johnson, Toby and den Heijer, Martin and Ketkar, Shamika and Lamina, Claudia and To, Kilpeläinen and Fisher, Eva and Moffatt, Miriam F. and Li, Shengxu and Ll, Bonnycastle and Johansson, Åsa and Aben, Katja Kk H. and Sr, Bornstein and Myers, Richard H. and Estrada, Karol and Van Wingerden, S. and Absher, Devin M. and Watanabe, Richard M. and Nl, Heard Costa and van Wingerden, Sophie and White, Charles Cc and Mj, Brown and Perry, John R. B. and Dixon, Anna L. and Narisu, Narisu and Peters, Marjolein J. and Glazer, Nicole L. and Ta, Buchanan and Goddard, Michael E. and Konig, Inke R. and Jj, Hottenga and Preuss, Michael and Ripatti, Samuli and Esko, Tõnu and Rivadeneira, Fernando and Ps, Chines and Scott, Laura J. and Eestrada, K. and Sandholt, Camilla and Wiklund, Fredrik and Timpson, Nicholas J. and Tyrer, Jonathan P. and In, Day and Lango Allen, Hana and Mf, Moffatt and Mr, Erdos and Jo, Jansson and Jansson, John-Olov and Jg, Eriksson and Lawrence, Robert W. and Eesko, T. and Barlassina, Christina and Pellikka, Niina and Mf, Facheris and Prokopenko, Inga and Rh, Myers and Sb, Felix and Rw, Lawrence and Shi, Jianxin and Jorgensen, Torben and Lehtimaeki, Terho and Chasman, Daniel I. and Thiering, Elisabeth and Nb, Freimer and Koenig, Inke R. and Cooper, Matthew N. and Jh, Park and Alavere, Helene and Tönjes, Anke and Pv, Gejman and Almgren, Peter and Ida Chen, Y.-D. and Aspelund, Thor and Alibrandi, Maria T. S. and Wl, McArdle and Balkau, Beverley and Investigators, MAGIC (Meta-Analyses of Glucose and Insulin-Related Traits Consortium) and Arnold, Alice M. and Ben-Shlomo, Yoav and Atwood, Larry D. and O'Donnell, Cj and Bergmann, Sven and Balmforth, Anthony J. and Heijer, Martin den and Biebermann, Heike and Bennett, Amanda J. and Bergman, Richard N. and Jr, Perry and Boes, Tanja and Ek, Speliotes and Blakemore, Alexandra I. F. and Busonero, Fabio and Mj, Peters and Bonnycastle, Lori Ll and Campbell, Harry and Bornstein, Stefan R. and Kb, Jacobs and Cavalcanti-Proença, Christine and Brown, Morris J. and Buchanan, Thomas A. and Clarke, Robert and Cappuccio, Francesco P. and Lm, Kaplan and Coin, Lachlan and Connell, John and Chen, Chih-Mei and Cm, Lindgren and Jw, Knowles and Chines, Peter S. and Duan, Jubao and Ir, König and Hm, Stringham and Au, Jackson and Day, Ian N. M. and König, Ir R. and Lj, Launer and Fischer-Posovszky, Pamela and Kusisto, J. and Friedrich, Nele and Jc, Randall and Ml, Lokki and Heath, Andrew C. and Fu, Mao and Mn, Weedon and Felix, Stephan B. and Hicks, Andrew Aa and Tw, Winkler and Facheris, Maurizio F. and Gaget, Stefan and Rn, Luben and Rj, Weyant and Hayward, Caroline and Folsom, Aaron R. and Platou, Carl G. P. and Hengstenberg, Christian and Gieger, Christian and Ng, Martin and Freimer, Nelson B. and Hinney, Anke and Jacobs, Kevin B. and Hofman, Albert and Goel, Anuj and Homuth, Georg and Goyette, Philippe and Jp, Beilby and Hui, Jennie and Gejman, Pablo V. and Elliott, Paul and Igl, Wilmar and Grallert, Harald and Geus, Eco J. C. and Elosua, Roberto and Iribarren, Carlos and Eiriksdottir, Gudny and Lj, Scott and Isomaa, Bo and Ma, Morken and Ebrahim, Shah and Gjesing, Anette P. and Gudnason, Vilmundur and Js, Beckmann and Jarick, Ivonne and Guiducci, Candace and Kaplan, Lee M. and Jewell, Elizabeth and Mj, Neville and John, Ulrich and Hassanali, Neelam and Js, Ngwa and Jørgensen, Torben and Jousilahti, Pekka and Jh, Zhao and Pietilaeinen, Kirsi H. and Jula, Antti and Gräßler, Jürgen and Knowles, Joshua W. and Kaakinen, Marika and Greenawalt, Danielle M. and Kajantie, Eero and Is, Farooqi and Mj, Caulfield and Groves, Christopher J. and Chen, Yii-Der Ida and Dm, Absher and Kathiresan, Sekar and Nj, Timpson and Pare, Guillaume and Kettunen, Johannes and Sj, Chanock and Kuusisto, Johanna and Kinnunen, Leena and Jp, Tyrer and Wh, Ouwehand and Hartikainen, Anna-Liisa and Kolcic, Ivana and Den Heijer, M. and Hall, Alistair S. and Rm, Watanabe and Koskinen, Seppo and Havulinna, Aki S. and Kovacs, Peter and Eebrahim, S. and La, Cupples and Launer, Lenore J. and Al, Dixon and Erdos, Michael R. and Kraft, Peter and Eriksson, Johan G. and Kvaløy, Kirsti and Laitinen, Jaana and Eelliott, P. and Lantieri, Olivier and Eelosua, R. and Lanzani, Chiara and Magic,  and Kk, Ong and Eeiriksdottir, G. and Lecoeur, Cecile and Eerdos, M. R. and Lokki, Marja-Liisa and Hv, Huikuri and Lehtimäki, Terho and Lettre, Guillaume and Luben, Robert N. and Liu, Jianjun and Di, Chasman and van Meurs, Joyce B. Jb and van Ommen, Gert-Jan and Lorentzon, Mattias and Eeriksson, J. G. and Am, Arnold and Ludwig, Barbara and Tl, Assimes and Martin, Nicholas G. and Aj, Balmforth and Manunta, Paolo and Aj, Bennett and Ib, Borecki and König, Inke R. and Marek, Diana and Tb, Harris and McArdle, Wendy L. and Marre, Michel and Rb, Hayes and Ai, Blakemore and Av, Segrè and McCarthy, Anne and McKnight, Barbara and Meitinger, Thomas and Melander, Olle and Meyre, David and Montgomery, Grant W. and Morken, Mario A. and Kh, Pietiläinen and Midthjell, Kristian and Fp, Cappuccio and Morris, Andrew P. and Schunkeret, Heribert and Cm, Chen and O'Ddonnell, C. J. and Mr, Jarvelin and Ngwa, Julius S. and Ms, Nieminen and Mulic, Rosanda and Oostra, Ben and Ar, Wood and Neville, Matt J. and Kt, Khaw and Av, Smith and Nelis, Mari and La, Kiemeney and Nyholt, Dale R. and Ostra, B. and O'Rahilly, Stephen and Ong, Ken Kk and Ar, Folsom and Paré, Guillaume and Sephens, Jonathan and Tm, Frayling and Parker, Alex N. and Lc, Groop and Perola, Markus and Nw, Rayner and Pb, Munroe and Pichler, Irene and Ej, Geus and Pietiläinen, Kirsi H. and Sadaf Farooqi, I. and Polasek, Ozren and Platou, C. P. and Pouta, Anneli and Ap, Gjesing and Rafelt, Suzanne and Nr, Robertson and Raitakari, Olli and Lj, Palmer and Vogel, Carla I. G. and Rayner, Nigel W. and Magi, Reedik and Rc, Kaplan and Voight, Benjamin F. and Ridderstråle, Martin and Dm, Greenawalt and Rief, Winfried and Sa, McCarroll and Waite, Lindsay Ll and Cc, White and Ruokonen, Aimo and Walters, Gb Bragi and Robertson, Neil R. and O’donnell, Christopher J. and Rzehak, Peter and Salomaa, Veikko and Jn, Hirschhorn and Cj, Groves and Sanders, Alan R. and Kaehoenen, Mika and Wild, Sarah H. and Sandhu, Manjinder S. and Sanna, Serena and As, Hall and Saramies, Jouko and Ms, Sandhu and Kahonen, Mika and Witte, Daniel R. and Savolainen, Markku J. and Al, Hartikainen and Witteman, Jacqueline C. and Scherag, Susann and Gräßler, Jürgen and Schipf, Sabine and Schreiber, Stefan and Schunkert, Heribert and Mj, Savolainen and Viikari, Jorma and Silander, Kaisa and As, Havulinna and Visvikis-Siest, Sophie and Sinisalo, Juha and Siscovick, David S. and Vitart, Veronique and Smit, Jan H. and Mi, McCarthy and Soranzo, Nicole and Sovio, Ulla and Ac, Heath and Stephens, Jonathan and Swift, Amy J. and Surakka, Ida and Wallaschofski, Henri and Aa, Hicks and Jh, Smit and Tammesoo, Mari-Liis and Tardif, Jean-Claude and Widen, Elisabeth and Wiegand, Susanna and Teslovich, Tanya M. and Teder-Laving, Maris and Thompson, John R. and Willemsen, Gonneke and Ke, North and Thomson, Brian and Tönjes, Anke and Pm, Ridker and Tuomi, Tiinamaija and Xu, Jianfeng and Jb, van Meurs and Zhang, Qunyuan and Jr, O'Connell and Ml, Tammesoo and Vatin, Vincent and Zgaga, Lina and Jc, Tardif and Ziegler, Andreas and Van Meurs, J. B. J. and Tm, Teslovich and Zitting, Paavo and Procardis, Consortium and Jr, Thompson and van Duijn, Cornelia M. and Van OMen, G.-J. and Pp, Pramstaller and Mccarroll, Steven A. and Ll, Waite and Sh, Wild and Jc, Witteman and O’connell, Jeffrey R. and Huikuri, Heikki V. and Gw, Montgomery and Hebebrand, Johannes and James, Alan L. and Ap, Morris and Nj, Samani and McCarthy, Mark I. and Kähönen, Mika and Levinson, Douglas F. and Dr, Nyholt and Beilby, John P. and Macciardi, Fabio and Other, And and Nieminen, Markku S. and Ohlsson, Claes and An, Parker and Palmer, Lyle J. and Ridker, Paul M. and Pe, Schwarz and Cg, Platou and Stumvoll, Michael and Smith, Gd D. and Td, Spector and Di, Boomsma and Beckmann, Jacques S. and Boeing, Heiner and Ar, Sanders and Boerwinkle, Eric and FarOqi, I. S. and Fs, Collins and Caulfield, Mark J. and Graessler, Juergen and Tt, Valle and Chanock, Stephen J. and Ds, Siscovick and Collins, Francis S. and Farooqi, Is Sadaf and Nj, Wareham and Cupples, La Adrienne and Hu, Frank B. and Hall, Per and Heinrich, Joachim and Jarvelin, Marjo-Riitta and Gyllensten, Ulf and Hveem, Kristian and Wareham, Nicholas J. and Pm, Visscher and Khaw, Kay-Tee and Illig, Thomas and Wilson, James F. and Jf, Wilson and Hansen, Torben and Erdmann, Jeanette and Wright, Alan F. and Grönberg, Henrik and Froguel, Philippe and Zillikens, Mc Carola and Kiemeney, Lambertus A. L. M. and Kaprio, Jaakko and Aj, Swift and Karpe, Fredrik and Al, James and Lawlor, Debbie A. and Krude, Heiko and Visscher, Peter M. and Gj, van Ommen and Boomsma, Dorret I. and Harris, Tamara B. and BOmsma, D. I. and Mc, Zillikens and Hattersley, Andrew T. and Laakso, Markku and Munroe, Patricia B. and Hayes, Richard B. and Wabitsch, Martin and Df, Levinson and Metspalu, Andres and Ouwehand, Willem H. and Waeber, Gerard and At, Hattersley and He, Wichmann and Penninx, Brenda W. and Ci, Vogel and Pedersen, Oluf and Watkins, Hugh and Bf, Voight and Peters, Annette and Pramstaller, Peter Pp and Wichmann, He-Erich and Gb, Walters and Quertermous, Thomas and Fb, Hu and Reinehr, Thomas and Gronberg, Henrik and Rissanen, Aila and Dr, Witte and Rudan, Igor and Gr, Abecasis and Cs, Fox and Samani, Nilesh J. and Schwarz, Peter E. H. and Eerdmann, J. and Shuldiner, Alan R. and Spector, Timothy D. (Timothy David) and Frogue, P. and O'Connell, Jeffrey R. and Tuomilehto, Jaakko and Da, Lawlor and Uda, Manuela and Gd, Smith and Uitterlinden, André and Valle, Timo Tt and Rj, Loos and Strachan, David P. and Bw, Penninx and McCarroll, Sa A. and O'ConneL,  and SchleSinger, D. and Schadt, Eric Ee and Chatterjee, Nilanjan and Purcell, Shaun and P. Strachan, D. P. and Van Duijn, C. and Ar, Shuldiner and Schlessinger, David and I. McCarthy, Mark and Hunter, David J. and Dj, Hunter and StefanSon, K. and Assimes, Themistocles L. and Deloukas, Panos and Ingelsson, Erik and Kaplan, Robert C. and Borecki, Ingrid B. and Bragi Walters, G. and Mohlke, Karen L. and McArthy, M. I. and Fox, Caroline S. and Ee, Schadt and ChatterjE, N. and Haritunians, Talin and IngelSon, E. and Groop, Leif C. and Peltonen, Leena and Stefansson, Kari and Consortium, on behalf of Procardis and Greonberg, Henrik and Af, Wright and Thorsteinsdottir, Unnur and Dp, Strachan and Frayling, Timothy M. and North, Kari E. and Adreienne Cupples, L. and Davey Smith, George and Hirschhorn, Joel N. and Abecasis, Gonçalo R. and Barroso, Inês and Grönberg, Henrik and Carola Zillikens, M. and Boehnke, Michael and Loos, Ruth J. F. and Cm, van Duijn and Erich Wichmann, H.},
  doi = {10.1038/ng.686},
  month = {oct},
  title = {Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index},
  url = {http://www.nature.com/articles/ng.686.pdf},
  year = {2010}
}

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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Journal article published in 2010 by S. van Wingerden, Cristen J. Willer, Elizabeth K. Speliotes, Willer Cj, Monda Kl, Keri L. Monda, Anne U. Jackson, Cecilia M. Lindgren, Gudmar Thorleifsson, Sonja I. Berndt, Joshua C. Randall, Reedik Mägi, Thomas W. Winkler, Tsegaselassie Workalemahu, Lu Qi and other authors. S. van Wingerden, Cristen J. Willer, Elizabeth K. Speliotes, Willer Cj, Monda Kl, Keri L. Monda, Anne U. Jackson, Cecilia M. Lindgren, Gudmar Thorleifsson, Sonja I. Berndt, Joshua C. Randall, Reedik Mägi, Thomas W. Winkler, Tsegaselassie Workalemahu, Lu Qi, Iris M. Heid, Jian’an Luan, Michael N. Weedon, Hana Lango Allen, Andrew R. Wood, Heather M. Stringham, Valgerdur Steinthorsdottir, Eleanor Wheeler, Robert J. Weyant, Sailaja Vedantam, Ayellet V. Segré, Aben Kk, Reedik Maegi, Liming Liang, Tuomas O. Kilpelaenen, Ju-Hyun Park, Reedik Mägi, Teresa Ferreira, James Nemesh, Jian Yang

, Berndt Si, Tuomas O. Kilpeläinen, To Kilpelanen, Anke Toenjes, Å. Johansson, Stefan Gustafsson, Jing Hua Zhao, Feitosa Mf, Zoltán Kutalik, Järvelin Mr, Massimo Mangino, Nabila Bouatia-Naji, Ryan Welch, Soumya Raychaudhuri, Heid Im, Albert Vernon Smith

, Andre Scherag, Alibrandi Mt, Atwood Ld, Mary F. Feitosa, Glazer Nl, Chen Yd, Nancy L. Heard-Costa, Goddard Me, Jouke-Jan Hottenga, Volker Hoesel, Cooper Mn, Bergman Rn, Najaf Amin, Toby Johnson

, Martin den Heijer, Shamika Ketkar, Claudia Lamina, Kilpeläinen To, Eva Fisher, Miriam F. Moffatt, Shengxu Li, Bonnycastle Ll, Åsa Johansson, Katja Kk H. Aben, Bornstein Sr, Richard H. Myers, Karol Estrada, S. Van Wingerden, Devin M. Absher, Richard M. Watanabe, Heard Costa Nl, Sophie van Wingerden, Charles Cc White, Brown Mj, John R. B. Perry, Anna L. Dixon, Narisu Narisu, Marjolein J. Peters, Nicole L. Glazer, Buchanan Ta, Michael E. Goddard, Inke R. Konig, Hottenga Jj, Michael Preuss

, Samuli Ripatti, Tõnu Esko

, Fernando Rivadeneira, Chines Ps, Laura J. Scott, K. Eestrada, Camilla Sandholt, Fredrik Wiklund, Nicholas J. Timpson

, Jonathan P. Tyrer, Day In, Hana Lango Allen, Moffatt Mf, Erdos Mr, Jansson Jo, John-Olov Jansson, Eriksson Jg, Robert W. Lawrence, T. Eesko, Christina Barlassina, Niina Pellikka, Facheris Mf, Inga Prokopenko

, Myers Rh, Felix Sb, Lawrence Rw, Jianxin Shi, Torben Jorgensen, Terho Lehtimaeki, Daniel I. Chasman, Elisabeth Thiering, Freimer Nb, Inke R. Koenig, Matthew N. Cooper, Park Jh, Helene Alavere, Anke Tönjes, Gejman Pv, Peter Almgren, Y.-D. Ida Chen, Thor Aspelund, Maria T. S. Alibrandi, McArdle Wl, Beverley Balkau, MAGIC (Meta-Analyses of Glucose and Insulin-Related Traits Consortium) Investigators, Alice M. Arnold, Yoav Ben-Shlomo, Larry D. Atwood, Cj O'Donnell, Sven Bergmann, Anthony J. Balmforth, Martin den Heijer, Heike Biebermann, Amanda J. Bennett, Richard N. Bergman, Perry Jr, Tanja Boes, Speliotes Ek, Alexandra I. F. Blakemore, Fabio Busonero, Peters Mj, Lori Ll Bonnycastle, Harry Campbell, Stefan R. Bornstein, Jacobs Kb, Christine Cavalcanti-Proença, Morris J. Brown, Thomas A. Buchanan, Robert Clarke, Francesco P. Cappuccio, Kaplan Lm, Lachlan Coin, John Connell, Chih-Mei Chen, Lindgren Cm, Knowles Jw, Peter S. Chines, Jubao Duan, König Ir, Stringham Hm, Jackson Au, Ian N. M. Day, Ir R. König, Launer Lj, Pamela Fischer-Posovszky, J. Kusisto, Nele Friedrich, Randall Jc, Lokki Ml, Andrew C. Heath, Mao Fu, Weedon Mn, Stephan B. Felix, Andrew Aa Hicks, Winkler Tw, Maurizio F. Facheris, Stefan Gaget, Luben Rn, Weyant Rj, Caroline Hayward, Aaron R. Folsom, Carl G. P. Platou, Christian Hengstenberg, Christian Gieger

, Martin Ng, Nelson B. Freimer, Anke Hinney, Kevin B. Jacobs, Albert Hofman, Anuj Goel, Georg Homuth, Philippe Goyette, Beilby Jp, Jennie Hui, Pablo V. Gejman, Paul Elliott, Wilmar Igl, Harald Grallert, Eco J. C. Geus, Roberto Elosua, Carlos Iribarren, Gudny Eiriksdottir, Scott Lj, Bo Isomaa, Morken Ma, Shah Ebrahim, Anette P. Gjesing, Vilmundur Gudnason, Beckmann Js, Ivonne Jarick, Candace Guiducci, Lee M. Kaplan, Elizabeth Jewell, Neville Mj, Ulrich John, Neelam Hassanali, Ngwa Js, Torben Jørgensen, Pekka Jousilahti, Zhao Jh, Kirsi H. Pietilaeinen, Antti Jula, Jürgen Gräßler, Joshua W. Knowles, Marika Kaakinen

, Danielle M. Greenawalt, Eero Kajantie, Farooqi Is, Caulfield Mj, Christopher J. Groves, Yii-Der Ida Chen, Absher Dm, Sekar Kathiresan, Timpson Nj, Guillaume Pare, Johannes Kettunen, Chanock Sj, Johanna Kuusisto, Leena Kinnunen, Tyrer Jp, Ouwehand Wh, Anna-Liisa Hartikainen, Ivana Kolcic, M. Den Heijer

, Alistair S. Hall, Watanabe Rm, Seppo Koskinen, Aki S. Havulinna, Peter Kovacs, S. Eebrahim, Cupples La, Lenore J. Launer, Dixon Al, Michael R. Erdos, Peter Kraft, Johan G. Eriksson, Kirsti Kvaløy, Jaana Laitinen, P. Eelliott, Olivier Lantieri, R. Eelosua, Chiara Lanzani, Magic, Ong Kk, G. Eeiriksdottir, Cecile Lecoeur, M. R. Eerdos, Marja-Liisa Lokki, Huikuri Hv, Terho Lehtimäki, Guillaume Lettre, Robert N. Luben

, Jianjun Liu, Chasman Di, Joyce B. Jb van Meurs, Gert-Jan van Ommen, Mattias Lorentzon, J. G. Eeriksson, Arnold Am, Barbara Ludwig, Assimes Tl, Nicholas G. Martin

, Balmforth Aj, Paolo Manunta, Bennett Aj, Borecki Ib, Inke R. König, Diana Marek, Harris Tb, Wendy L. McArdle, Michel Marre, Hayes Rb, Blakemore Ai, Segrè Av, Anne McCarthy, Barbara McKnight, Thomas Meitinger, Olle Melander, David Meyre, Grant W. Montgomery, Mario A. Morken, Pietiläinen Kh, Kristian Midthjell, Cappuccio Fp, Andrew P. Morris, Heribert Schunkeret, Chen Cm, C. J. O'Ddonnell, Jarvelin Mr, Julius S. Ngwa, Nieminen Ms, Rosanda Mulic, Ben Oostra, Wood Ar, Matt J. Neville, Khaw Kt, Smith Av, Mari Nelis, Kiemeney La, Dale R. Nyholt

, B. Ostra, Stephen O'Rahilly, Ken Kk Ong, Folsom Ar, Guillaume Paré, Jonathan Sephens, Frayling Tm, Alex N. Parker, Groop Lc, Markus Perola, Rayner Nw, Munroe Pb, Irene Pichler

, Geus Ej, Kirsi H. Pietiläinen, I. Sadaf Farooqi, Ozren Polasek, C. P. Platou, Anneli Pouta, Gjesing Ap, Suzanne Rafelt, Robertson Nr, Olli Raitakari, Palmer Lj, Carla I. G. Vogel, Nigel W. Rayner, Reedik Magi, Kaplan Rc, Benjamin F. Voight, Martin Ridderstråle, Greenawalt Dm, Winfried Rief, McCarroll Sa, Lindsay Ll Waite, White Cc, Aimo Ruokonen, Gb Bragi Walters, Neil R. Robertson, Christopher J. O’donnell, Peter Rzehak, Veikko Salomaa, Hirschhorn Jn, Groves Cj, Alan R. Sanders, Mika Kaehoenen, Sarah H. Wild, Manjinder S. Sandhu, Serena Sanna

, Hall As, Jouko Saramies, Sandhu Ms, Mika Kahonen, Daniel R. Witte

, Markku J. Savolainen, Hartikainen Al, Jacqueline C. Witteman, Susann Scherag, Jürgen Gräßler, Sabine Schipf, Stefan Schreiber, Heribert Schunkert, Savolainen Mj, Jorma Viikari, Kaisa Silander, Havulinna As, Sophie Visvikis-Siest, Juha Sinisalo, David S. Siscovick, Veronique Vitart, Jan H. Smit, McCarthy Mi, Nicole Soranzo, Ulla Sovio, Heath Ac, Jonathan Stephens, Amy J. Swift, Ida Surakka, Henri Wallaschofski, Hicks Aa, Smit Jh, Mari-Liis Tammesoo, Jean-Claude Tardif, Elisabeth Widen, Susanna Wiegand, Tanya M. Teslovich, Maris Teder-Laving, John R. Thompson, Gonneke Willemsen, North Ke, Brian Thomson, Anke Tönjes, Ridker Pm, Tiinamaija Tuomi, Jianfeng Xu, van Meurs Jb, Qunyuan Zhang, O'Connell Jr, Tammesoo Ml, Vincent Vatin, Lina Zgaga, Tardif Jc, Andreas Ziegler, J. B. J. Van Meurs, Teslovich Tm, Paavo Zitting, Consortium Procardis, Thompson Jr, Cornelia M. van Duijn, G.-J. Van OMen, Pramstaller Pp, Steven A. Mccarroll, Waite Ll, Wild Sh, Witteman Jc, Jeffrey R. O’connell, Heikki V. Huikuri, Montgomery Gw, Johannes Hebebrand, Alan L. James, Morris Ap, Samani Nj, Mark I. McCarthy, Mika Kähönen, Douglas F. Levinson, Nyholt Dr, John P. Beilby, Fabio Macciardi, And Other, Markku S. Nieminen, Claes Ohlsson, Parker An, Lyle J. Palmer, Paul M. Ridker, Schwarz Pe, Platou Cg, Michael Stumvoll, Gd D. Smith, Spector Td, Boomsma Di, Jacques S. Beckmann, Heiner Boeing, Sanders Ar, Eric Boerwinkle, I. S. FarOqi, Collins Fs, Mark J. Caulfield, Juergen Graessler, Valle Tt, Stephen J. Chanock, Siscovick Ds, Francis S. Collins, Is Sadaf Farooqi

, Wareham Nj, La Adrienne Cupples, Frank B. Hu, Per Hall, Joachim Heinrich, Marjo-Riitta Jarvelin, Ulf Gyllensten, Kristian Hveem, Nicholas J. Wareham, Visscher Pm, Kay-Tee Khaw, Thomas Illig, James F. Wilson, Wilson Jf, Torben Hansen, Jeanette Erdmann, Alan F. Wright, Henrik Grönberg, Philippe Froguel, Mc Carola Zillikens, Lambertus A. L. M. Kiemeney, Jaakko Kaprio, Swift Aj, Fredrik Karpe, James Al, Debbie A. Lawlor, Heiko Krude, Peter M. Visscher, van Ommen Gj, Dorret I. Boomsma, Tamara B. Harris, D. I. BOmsma, Zillikens Mc, Andrew T. Hattersley, Markku Laakso, Patricia B. Munroe, Richard B. Hayes

, Martin Wabitsch, Levinson Df, Andres Metspalu, Willem H. Ouwehand, Gerard Waeber, Hattersley At, Wichmann He, Brenda W. Penninx, Vogel Ci, Oluf Pedersen, Hugh Watkins, Voight Bf, Annette Peters, Peter Pp Pramstaller

, He-Erich Wichmann, Walters Gb, Thomas Quertermous, Hu Fb, Thomas Reinehr, Henrik Gronberg, Aila Rissanen, Witte Dr, Igor Rudan, Abecasis Gr, Fox Cs, Nilesh J. Samani, Peter E. H. Schwarz, J. Eerdmann, Alan R. Shuldiner, Timothy D. (Timothy David) Spector, P. Frogue, Jeffrey R. O'Connell, Jaakko Tuomilehto, Lawlor Da, Manuela Uda, Smith Gd, André Uitterlinden, Timo Tt Valle, Loos Rj, David P. Strachan, Penninx Bw, Sa A. McCarroll, O'ConneL, D. SchleSinger, Eric Ee Schadt, Nilanjan Chatterjee, Shaun Purcell, D. P. P. Strachan, C. Van Duijn, Shuldiner Ar, David Schlessinger, Mark I. McCarthy, David J. Hunter, Hunter Dj, K. StefanSon, Themistocles L. Assimes, Panos Deloukas

, Erik Ingelsson, Robert C. Kaplan, Ingrid B. Borecki, G. Bragi Walters, Karen L. Mohlke, M. I. McArthy, Caroline S. Fox, Schadt Ee, N. ChatterjE, Talin Haritunians, E. IngelSon, Leif C. Groop, Leena Peltonen, Kari Stefansson, on behalf of Procardis Consortium, Henrik Greonberg, Wright Af, Unnur Thorsteinsdottir, Strachan Dp, Timothy M. Frayling, Kari E. North, L. Adreienne Cupples, George Davey Smith, Joel N. Hirschhorn, Gonçalo R. Abecasis, Inês Barroso, Henrik Grönberg, M. Carola Zillikens, Michael Boehnke, Ruth J. F. Loos, van Duijn Cm, H. Erich Wichmann

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Abstract

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10⁻⁸), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Abstract