Published in
Royal Society of Chemistry, Dalton Transactions, 3(39), p. 704-706
DOI: 10.1039/b919119b
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Fluorescence properties and cellular distribution of the investigational anticancer drugTriapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(ii) complex
Journal article published in 2010 by
Christian R. Kowol,
Robert Trondl,
Vladimir B. Arion,
Michael A. Jakupec 
,
Irene Lichtscheidl,
Bernhard K. Keppler
,
Irene Lichtscheidl,
Bernhard K. Keppler
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Abstract
Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), which entered several phase I and II clinical trials as an antitumor chemotherapeutic agent, was found to possess intrinsic fluorescence properties (lambda(ex) = 360 nm), which enabled us to monitor the uptake and intracellular distribution in living human cancer cells by fluorescence microscopy.