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Nature Research, Nature, 7414(489), p. 101-108, 2012

DOI: 10.1038/nature11233

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Landscape of transcription in human cells

Journal article published in 2012 by Sarah Djebali, Carrie A. Davis, Angelika Merkel, Alex Dobin, Timo Lassmann ORCID, Ali M. Mortazavi, Andrea Tanzer ORCID, Julien Lagarde, Wei Lin, Felix Schlesinger, Chenghai Xue, Georgi K. Marinov, Jainab Khatun, Brian A. Williams, Chris Zaleski and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Eukaryotic cells make many types of primary and processed RNAs that are found either in specific sub-cellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic sub-cellular localizations are also poorly understood. Since RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell’s regulatory capabilities are focused on its synthesis, processing, transport, modifications and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three quarters of the human genome is capable of being transcribed, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs. These observations taken together prompt to a redefinition of the concept of a gene.