Topological insulators have exotic surface states that are massless Dirac fermions, manifesting special magnetotransport properties, such as the Aharonov-Bohm effect, Shubnikov-de Haas oscillations, and weak antilocalization effects. In the surface Dirac cone, the band structures are typically closely related to the p-orbitals and possess helical orbital texture. Here we report on the tunability of the transport properties via the interaction between the magnetic field and the spin-orbital angular momentum of the surface states in individual Bi2Se3 nanoribbons. Because the surface states have a large Landé factor and helical spin-orbital texture, the in-plane magnetic field induced Zeeman energy will result in the deformation of the Dirac cone, which gives rise to spin polarization of the surface states. The spin-dependent scattering of the conducting electrons on the existing local magnetic moments produces a giant negative magnetoresistance. The negative magnetoresistance is robust with a ratio of -20% at 2 K and -0.5% at 300 K under 14 T. The results are valuable for possible orbital-electronics based on topological insulators.