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Royal Society of Chemistry, Chemical Communications, 73(50), p. 10687

DOI: 10.1039/c4cc03320e

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The Au Clusters Induce Tumor Cell Apoptosis via Specifically Targeting Thioredoxin Reductase 1 (TrxR1) and Suppressing its Activity

Journal article published in 2014 by Ru Liu, Yaling Wang ORCID, Qing Yuan, Deyi An, Jingyuan Li ORCID, Xueyun Gao
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Au25 clusters stabilized by tridecapeptides were firstly synthesized, which can well penetrate the cell membrane and exactly locate in the cytoplasm. Hence the Au clusters significantly suppress the TrxR1 activity in cytoplasm, and further induce the up-regulation of activated PARP level which carries the tumor cell apoptosis in Au dose dependent manner