Mixing of zeolites with different pore size enhances the yield of skeletal isomers from pure n-alkanes, but this synergic effect is limited in n-alkane mixtures because of preferential adsorption and cracking of the longest molecules. Single-Event MicroKinetic (SEMK) analysis reveals that enhanced yields of skeletal isomers can be obtained even with n-alkane mixtures, provided the hydroisomerization reaction is performed under liquid-phase reaction conditions. Skeletal isomerization of linear alkanes is an essential process of fossil as well as renewable hydrocarbon fuel and lubricant production. The SEMK model enables the selection of optimum catalyst formulation and reaction conditions for superior paraffinic wax hydroconversion.